Literature DB >> 8791107

Immunochemical study of transforming growth factor-beta in the kidney of the rat and chicken.

C Díaz-Ruiz1, B Montaner, R Pérez-Tomás.   

Abstract

Transforming growth factor-beta (TGF-beta) is a homodimeric polypeptide of 25 kDa, which regulates cell growth and differentiation and influences extracellular matrix metabolism. Using immunochemical techniques, we identified TGF-beta in the loops of Henle and the collecting and Bellini ducts of rat kidney and in the loops of Henle of chicken kidney. Furthermore, we detected two TGF-beta-immunoreactive proteins on kidney blots of the rat of 12.5 and 47 kDa, and three on chicken kidney blots of 12.5, 34, and 47 kDa. We suggest that the precursor forms of rat and chicken TGF-beta 2 or beta 3, chicken TGF-beta 4, and the mature form of all of them are expressed in the collecting and Bellini ducts of rat kidney and the loops of Henle of rat and chicken kidney.

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Year:  1996        PMID： 8791107     DOI： 10.1007/bf01457661

Source DB:  PubMed          Journal:  Histochem Cell Biol        ISSN： 0948-6143            Impact factor:   4.304


  18 in total

1.  Expression of transforming growth factor-beta 1 and beta 2 in rat glomeruli.

Authors:  K MacKay; P Kondaiah; D Danielpour; H A Austin; P D Brown
Journal:  Kidney Int       Date:  1990-12       Impact factor: 10.612

2.  Elevated glucose stimulates TGF-beta gene expression and bioactivity in proximal tubule.

Authors:  M V Rocco; Y Chen; S Goldfarb; F N Ziyadeh
Journal:  Kidney Int       Date:  1992-01       Impact factor: 10.612

3.  Growth factors from murine sarcoma virus-transformed cells.

Authors:  J E de Larco; G J Todaro
Journal:  Proc Natl Acad Sci U S A       Date:  1978-08       Impact factor: 11.205

4.  Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa.

Authors:  H Schägger; G von Jagow
Journal:  Anal Biochem       Date:  1987-11-01       Impact factor: 3.365

5.  Transforming growth factor-beta in rat kidney during compensatory renal growth.

Authors:  S Kanda; T Igawa; M Taide; J Eguchi; M Nakamura; K Nomata; J Yamada; H Kanetake; Y Saito
Journal:  Growth Regul       Date:  1993-06

6.  Expression of transforming growth factor-beta 1 during diabetic renal hypertrophy.

Authors:  S J Shankland; J W Scholey; H Ly; K Thai
Journal:  Kidney Int       Date:  1994-08       Impact factor: 10.612

7.  Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy.

Authors:  T Yamamoto; T Nakamura; N A Noble; E Ruoslahti; W A Border
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-01       Impact factor: 11.205

8.  Metanephric transforming growth factor-beta 1 regulates nephrogenesis in vitro.

Authors:  S A Rogers; G Ryan; A F Purchio; M R Hammerman
Journal:  Am J Physiol       Date:  1993-06

9.  Nucleotide sequence of chicken transforming growth factor-beta 1 (TGF-beta 1).

Authors:  S B Jakowlew; P J Dillard; M B Sporn; A B Roberts
Journal:  Nucleic Acids Res       Date:  1988-09-12       Impact factor: 16.971

10.  A role for TGF-beta in oligodendrocyte differentiation.

Authors:  R D McKinnon; G Piras; J A Ida; M Dubois-Dalcq
Journal:  J Cell Biol       Date:  1993-06       Impact factor: 10.539
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