OBJECTIVE: To search for a deterioration threshold of synaptic ultrastructure in physiologic aging and senile dementia of Alzheimer's type (SDAT). STUDY DESIGN: The numerical density (Nu), average area (S) and surface density (Su) of the synaptic contact zones were investigated in the hippocampus and cerebellum from adults, elderly and SDAT patients by means of computer-assisted morphometry. RESULTS: The Nu and surface Su densities of the synapses decreased while the size of S enlarged in elderly and SDAT patients vs. the adults. By plotting Nu vs. S, the adult group showed a very high percentage of small junctions. In contrast, elderly and dementia patients demonstrated two overlapping populations of enlarged contacts. In SDAT the synapse-to-neuron ratio was decreased by 48% in the hippocampus and by 56% in the cerebellum. CONCLUSION: Our findings support the concept that the degeneration of synaptic contacts per se should be considered a crucial step in the progression of senile dementia, but the identification of a discrete deterioration threshold of synaptic morphology between aging and SDAT is not feasible at present.
OBJECTIVE: To search for a deterioration threshold of synaptic ultrastructure in physiologic aging and senile dementia of Alzheimer's type (SDAT). STUDY DESIGN: The numerical density (Nu), average area (S) and surface density (Su) of the synaptic contact zones were investigated in the hippocampus and cerebellum from adults, elderly and SDATpatients by means of computer-assisted morphometry. RESULTS: The Nu and surface Su densities of the synapses decreased while the size of S enlarged in elderly and SDATpatients vs. the adults. By plotting Nu vs. S, the adult group showed a very high percentage of small junctions. In contrast, elderly and dementiapatients demonstrated two overlapping populations of enlarged contacts. In SDAT the synapse-to-neuron ratio was decreased by 48% in the hippocampus and by 56% in the cerebellum. CONCLUSION: Our findings support the concept that the degeneration of synaptic contacts per se should be considered a crucial step in the progression of senile dementia, but the identification of a discrete deterioration threshold of synaptic morphology between aging and SDAT is not feasible at present.
Authors: Erik Portelius; Henrik Zetterberg; Tobias Skillbäck; Ulrika Törnqvist; Ulf Andreasson; John Q Trojanowski; Michael W Weiner; Leslie M Shaw; Niklas Mattsson; Kaj Blennow Journal: Brain Date: 2015-09-15 Impact factor: 13.501
Authors: Andrew P Merluzzi; Cynthia M Carlsson; Sterling C Johnson; Suzanne E Schindler; Sanjay Asthana; Kaj Blennow; Henrik Zetterberg; Barbara B Bendlin Journal: Neurology Date: 2018-06-29 Impact factor: 9.910
Authors: J R Bamburg; B W Bernstein; R C Davis; K C Flynn; C Goldsbury; J R Jensen; M T Maloney; I T Marsden; L S Minamide; C W Pak; A E Shaw; I Whiteman; O Wiggan Journal: Curr Alzheimer Res Date: 2010-05 Impact factor: 3.498