Literature DB >> 8790709

Some recent trends and progress in nucleoside synthesis.

H Vorbrüggen1.   

Abstract

Some recent progress concerning the optimal combinations of Lewis acids and solvents for the synthesis of pyrimidine as well as purine nucleosides is reviewed. Furthermore, the novel condensation of persilylated free sugars and heterocyclic bases in the presence of trimethylsilyl triflate to the corresponding persilylated nucleosides is discussed.

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Year:  1996        PMID： 8790709

Source DB:  PubMed          Journal:  Acta Biochim Pol        ISSN： 0001-527X            Impact factor:   2.149


  2 in total

1.  An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides.

Authors:  Ysobel R Baker; Cameron Thorpe; Jinfeng Chen; Laura M Poller; Lina Cox; Pawan Kumar; Wooi F Lim; Lillian Lie; Graham McClorey; Sven Epple; Daniel Singleton; Michael A McDonough; Jack S Hardwick; Kirsten E Christensen; Matthew J A Wood; James P Hall; Afaf H El-Sagheer; Tom Brown
Journal:  Nat Commun       Date:  2022-07-12       Impact factor: 17.694

2.  Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs.

Authors:  Guillermo Vasquez; Graeme C Freestone; W Brad Wan; Audrey Low; Cheryl Li De Hoyos; Jinghua Yu; Thazha P Prakash; Michael E Ǿstergaard; Xue-Hai Liang; Stanley T Crooke; Eric E Swayze; Michael T Migawa; Punit P Seth
Journal:  Nucleic Acids Res       Date:  2021-02-26       Impact factor: 16.971
  2 in total

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