Literature DB >> 8790512

Use of anonymous newborn serosurveys to evaluate antenatal HIV screening programmes.

F J Holland1, A E Ades, C F Davison, S Parker, T Berry, M Hjelm, A H Wilcox, D Cubitt, C N Hudson, C S Peckham.   

Abstract

OBJECTIVE: To evaluate the extent to which antenatal HIV screening programmes identify HIV infected women who go to term.
DESIGN: Comparison of results of two surveillance systems. An anonymous neonatal HIV serosurvey was used to estimate the numbers of HIV infected women giving birth; reporting by obstetricians was used to assess the proportion who had been identified.
SETTING: Three Thames regions.
RESULTS: 729,105 neonatal blood samples were tested, of which 484 were HIV seropositive. Newborn HIV seroprevalence is increasing, at different rates, in inner London, suburban London, and in non-metropolitan districts. During the past four years the proportion of infected women who have been identified before delivery is 16.9%, but less than half of these were diagnosed during pregnancy. In 1993 only five of the 128 (4%) previously undiagnosed infected women delivering babies were identified by antenatal screening.
CONCLUSION: Despite increased emphasis on antenatal testing for HIV in areas of higher prevalence the number of undiagnosed women delivering babies continues to increase. Consideration should be given to alternative strategies for offering antenatal HIV testing. Antenatal screening programmes should be monitored continuously by comparing anonymous neonatal seroprevalence with clinical reports from obstetricians.

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Year:  1994        PMID: 8790512     DOI: 10.1177/096914139400100308

Source DB:  PubMed          Journal:  J Med Screen        ISSN: 0969-1413            Impact factor:   2.136


  5 in total

1.  Unsuspected HIV infection presenting in first year of life.

Authors:  J A Evans; S C Marriage; M D Walters; M Levin
Journal:  BMJ       Date:  1995-05-13

2.  Descriptive survey of antenatal HIV testing in London: policy, uptake, and detection.

Authors:  S E MacDonagh; J Masters; B A Helps; P A Tookey; A E Ades; D M Gibb
Journal:  BMJ       Date:  1996-08-31

3.  Direct estimates of prevalent HIV infection in adults in England and Wales for 1991 and 1993: an improved method.

Authors:  A Petruckevitch; A Nicoll; A M Johnson; D Bennett
Journal:  Genitourin Med       Date:  1997-10

4.  Incidence of human immunodeficiency virus antibody in a prenatal population at a community hospital.

Authors:  T S Alexander; J Lee; B Yen-Lieberman
Journal:  Clin Diagn Lab Immunol       Date:  1999-01

5.  Voluntary, named testing for HIV in a community based antenatal clinic: a pilot study.

Authors:  I L Chrystie; C D Wolfe; J Kennedy; L Zander; A Tilzey; J E Banatvala
Journal:  BMJ       Date:  1995-10-07
  5 in total

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