Literature DB >> 8789374

Stimulation of cyclic AMP formation in the circular smooth muscle of human colon by activation of 5-HT4-like receptors.

P G McLean1, I M Coupar.   

Abstract

5-HT stimulated cyclic AMP generation in human colonic circular smooth muscle in a concentration-dependent fashion (EC50 = 229.1 nM). DAU 6236 also increased cyclic AMP formation and was a partial agonist relative to 5-HT. GR 113808 inhibited the cyclic AMP formation induced by 5-HT with a -log Ki value of 9.1 and an apparent pA2 value of 9.2. Ondansetron and methysergide failed to inhibit cyclic AMP formation induced by 5-HT. These results indicate that the 5-HT4 receptors of human colonic circular muscle mediate relaxation and inhibition of spontaneous contractions via formation of cyclic AMP.

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Year:  1996        PMID： 8789374      PMCID： PMC1909258          DOI： 10.1111/j.1476-5381.1996.tb15182.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  5 in total

1.  A comparative study of functional 5-HT4 receptors in human colon, rat oesophagus and rat ileum.

Authors:  P G McLean; I M Coupar; P Molenaar
Journal:  Br J Pharmacol       Date:  1995-05       Impact factor: 8.739

2.  Histamine-induced increases in cyclic AMP levels in bovine adrenal medullary cells.

Authors:  P D Marley; K A Thomson; K Jachno; M J Johnston
Journal:  Br J Pharmacol       Date:  1991-12       Impact factor: 8.739

3.  Blockade of human atrial 5-HT4 receptors by GR 113808.

Authors:  A J Kaumann
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

Review 4.  International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).

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Journal:  Pharmacol Rev       Date:  1994-06       Impact factor: 25.468

5.  Characterization of the 5-hydroxytryptamine receptor type involved in inhibition of spontaneous activity of human isolated colonic circular muscle.

Authors:  F S Tam; K Hillier; K T Bunce
Journal:  Br J Pharmacol       Date:  1994-09       Impact factor: 8.739
  5 in total
  8 in total

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Authors:  Masahiro Tajika; Yasumasa Niwa; Vikram Bhatia; Hiroki Kawai; Shinya Kondo; Akira Sawaki; Nobumasa Mizuno; Kazuo Hara; Susumu Hijioka; Kazuya Matsumoto; Yuji Kobayashi; Akira Saeki; Asana Akabane; Koji Komori; Kenji Yamao
Journal:  World J Gastroenterol       Date:  2012-05-28       Impact factor: 5.742

7.  5-HT decreases contractile and electrical activities in lymphatic vessels of the guinea-pig mesentery: role of 5-HT 7-receptors.

Authors:  Alice K Chan; Pierre-Yves von der Weid
Journal:  Br J Pharmacol       Date:  2003-05       Impact factor: 8.739

8.  Further investigation into the signal transduction mechanism of the 5-HT4-like receptor in the circular smooth muscle of human colon.

Authors:  P G McLean; I M Coupar
Journal:  Br J Pharmacol       Date:  1996-06       Impact factor: 8.739
  8 in total

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