Literature DB >> 8787921

Comparison of fluconazole and amphotericin B for treatment of experimental Candida albicans endocarditis in rabbits.

K Chemlal1, L Saint-Julien, V Joly, R Farinotti, N Seta, P Yeni, C Carbon.   

Abstract

Amphotericin B (AmB) and fluconazole, administered intraperitoneally for 7 days, were compared in a rabbit model for Candida albicans endocarditis. When given early, AmB was more effective than fluconazole for reducing CFU counts in vegetations (P < 0.01) and kidneys. Forty-eight hours after the last dose, AmB was still detected in all vegetations whereas fluconazole was detected in only one case.

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Year:  1996        PMID： 8787921      PMCID： PMC163098     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

Review 1.  In vitro antifungal susceptibility testing and measurement of levels of antifungal agents in body fluids.

Authors:  D J Drutz
Journal:  Rev Infect Dis       Date:  1987 Mar-Apr

2.  Tissue penetration of amphotericin B in Candida endocarditis.

Authors:  E Rubinstein; E R Noriega; M S Simberkoff; J J Rahal
Journal:  Chest       Date:  1974-10       Impact factor: 9.410

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Journal:  Br J Exp Pathol       Date:  1972-02

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Journal:  Am Heart J       Date:  1969-06       Impact factor: 4.749

5.  Effects of preventive, early, and late antifungal chemotherapy with fluconazole in different granulocytopenic models of experimental disseminated candidiasis.

Authors:  T J Walsh; S Aoki; F Mechinaud; J Bacher; J Lee; M Rubin; P A Pizzo
Journal:  J Infect Dis       Date:  1990-04       Impact factor: 5.226

6.  Efficacy of fluconazole in prophylaxis and treatment of experimental Candida endocarditis.

Authors:  L P Longman; S A Hibbert; M V Martin
Journal:  Rev Infect Dis       Date:  1990 Mar-Apr

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Authors:  M A Sande; C R Bowman; R A Calderone
Journal:  Infect Immun       Date:  1977-07       Impact factor: 3.441

8.  Fluconazole for life-threatening fungal infections in patients who cannot be treated with conventional antifungal agents.

Authors:  P A Robinson; A K Knirsch; J A Joseph
Journal:  Rev Infect Dis       Date:  1990 Mar-Apr

Review 9.  Azole antifungal agents: emphasis on new triazoles.

Authors:  M S Saag; W E Dismukes
Journal:  Antimicrob Agents Chemother       Date:  1988-01       Impact factor: 5.191

10.  Fluconazole penetration in cerebral parenchyma in humans at steady state.

Authors:  F Thaler; B Bernard; M Tod; C P Jedynak; O Petitjean; P Derome; P Loirat
Journal:  Antimicrob Agents Chemother       Date:  1995-05       Impact factor: 5.191
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  5 in total

1.  Impact of the order of initiation of fluconazole and amphotericin B in sequential or combination therapy on killing of Candida albicans in vitro and in a rabbit model of endocarditis and pyelonephritis.

Authors:  A Louie; P Kaw; P Banerjee; W Liu; G Chen; M H Miller
Journal:  Antimicrob Agents Chemother       Date:  2001-02       Impact factor: 5.191

2.  Efficacies of high-dose fluconazole plus amphotericin B and high-dose fluconazole plus 5-fluorocytosine versus amphotericin B, fluconazole, and 5-fluorocytosine monotherapies in treatment of experimental endocarditis, endophthalmitis, and pyelonephritis due to Candida albicans.

Authors:  A Louie; W Liu; D A Miller; A C Sucke; Q F Liu; G L Drusano; M Mayers; M H Miller
Journal:  Antimicrob Agents Chemother       Date:  1999-12       Impact factor: 5.191

3.  Fungicidal synergism of fluconazole and cyclosporine in Candida albicans is not dependent on multidrug efflux transporters encoded by the CDR1, CDR2, CaMDR1, and FLU1 genes.

Authors:  Oscar Marchetti; Philippe Moreillon; Josè M Entenza; Jacques Vouillamoz; Michel P Glauser; Jacques Bille; Dominique Sanglard
Journal:  Antimicrob Agents Chemother       Date:  2003-05       Impact factor: 5.191

4.  Fluconazole plus cyclosporine: a fungicidal combination effective against experimental endocarditis due to Candida albicans.

Authors:  O Marchetti; J M Entenza; D Sanglard; J Bille; M P Glauser; P Moreillon
Journal:  Antimicrob Agents Chemother       Date:  2000-11       Impact factor: 5.191

5.  Activities and ultrastructural effects of antifungal combinations against simulated Candida endocardial vegetations.

Authors:  Manjunath P Pai; Marie L Samples; Renee-Claude Mercier; Michael N Spilde
Journal:  Antimicrob Agents Chemother       Date:  2008-04-21       Impact factor: 5.191
  5 in total

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