Literature DB >> 8787912

Absence of effect of trimethoprim-sulfamethoxazole on pharmacokinetics of zidovudine in patients infected with human immunodeficiency virus.

E Cañas1, J Pachon, F Garcia-Pesquera, J R Castillo, P Viciana, J M Cisneros, M E Jimenez-Mejias.   

Abstract

Pharmacokinetic parameters of zidovudine (ZDV) were not altered in 16 patients receiving concomitant therapy with ZDV and trimethoprim-sulfamethoxazole by oral administration. ZDV areas under the concentration-time curves were (means +/- standard deviations) 1.80 +/- 0.70 and 1.69 +/- 0.64 micrograms.h/ml in the absence and presence of trimethoprim-sulfamethoxazole, respectively. ZDV clearances were 1.57 +/- 0.61 and 1.74 +/- 0.66 liters/h/kg, respectively.

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Year:  1996        PMID： 8787912      PMCID： PMC163089     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

Review 1.  Clinical pharmacokinetics of zidovudine. An overview of current data.

Authors:  J M Collins; J D Unadkat
Journal:  Clin Pharmacokinet       Date:  1989-07       Impact factor: 6.447

2.  In vitro inhibition studies of the glucuronidation of 3'-azido-3'-deoxythymidine catalysed by human liver UDP-glucuronosyl transferase.

Authors:  R Macleod; V A Eagling; S M Sim; D J Back
Journal:  Biochem Pharmacol       Date:  1992-01-22       Impact factor: 5.858

3.  Endocarditis due to Streptococcus morbillorum.

Authors:  S Maxwell
Journal:  J Infect       Date:  1989-01       Impact factor: 6.072

4.  3'-Azido-3'-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase.

Authors:  M H St Clair; C A Richards; T Spector; K J Weinhold; W H Miller; A J Langlois; P A Furman
Journal:  Antimicrob Agents Chemother       Date:  1987-12       Impact factor: 5.191

5.  Pharmacokinetics and bioavailability of zidovudine in humans.

Authors:  M R Blum; S H Liao; S S Good; P de Miranda
Journal:  Am J Med       Date:  1988-08-29       Impact factor: 4.965

6.  Azidothymidine steady-state pharmacokinetics in patients with AIDS and AIDS-related complex.

Authors:  O L Laskin; P de Miranda; M R Blum
Journal:  J Infect Dis       Date:  1989-04       Impact factor: 5.226

7.  PKCALC: a BASIC interactive computer program for statistical and pharmacokinetic analysis of data.

Authors:  R C Shumaker
Journal:  Drug Metab Rev       Date:  1986       Impact factor: 4.518

Review 8.  Zidovudine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy.

Authors:  H D Langtry; D M Campoli-Richards
Journal:  Drugs       Date:  1989-04       Impact factor: 9.546

9.  Radioimmunoassay for Retrovir, an anti-human immunodeficiency virus drug.

Authors:  R P Quinn; B Orban; S Tadepalli
Journal:  J Immunoassay       Date:  1989

10.  Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

Authors:  P A Furman; J A Fyfe; M H St Clair; K Weinhold; J L Rideout; G A Freeman; S N Lehrman; D P Bolognesi; S Broder; H Mitsuya
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205
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  4 in total

Review 1.  Effects of the antifungal agents on oxidative drug metabolism: clinical relevance.

Authors:  K Venkatakrishnan; L L von Moltke; D J Greenblatt
Journal:  Clin Pharmacokinet       Date:  2000-02       Impact factor: 6.447

2.  Pharmacokinetic interaction between zidovudine and trimethoprim/sulphamethoxazole in HIV-1 infected children.

Authors:  S Dallas; S E Read; S King; G Koren; R Bendayan
Journal:  Can J Infect Dis       Date:  2000-09

3.  Prevalence and management of drug-drug interactions with antiretroviral treatment in 2069 people living with HIV in rural Tanzania: a prospective cohort study.

Authors:  C Schlaeppi; F Vanobberghen; G Sikalengo; T R Glass; R C Ndege; G Foe; A Kuemmerle; D H Paris; M Battegay; C Marzolini; M Weisser
Journal:  HIV Med       Date:  2019-09-18       Impact factor: 3.180

4.  Pharmacokinetics of mefloquine and its effect on sulfamethoxazole and trimethoprim steady-state blood levels in intermittent preventive treatment (IPTp) of pregnant HIV-infected women in Kenya.

Authors:  Michael Green; Kephas Otieno; Abraham Katana; Laurence Slutsker; Simon Kariuki; Peter Ouma; Raquel González; Clara Menendez; Feiko ter Kuile; Meghna Desai
Journal:  Malar J       Date:  2016-01-05       Impact factor: 2.979
  4 in total

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