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Literature DB >> 8787801

Characterization of binding site of uremic toxins on human serum albumin.

Abstract

The interaction of uremic toxins including indole-3-acetic acid (IA), indoxyl sulfate (IS), hippuric acid (HA) and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) with human serum albumin (HSA) has been investigated by three methods of fluorescent probe displacement, ultrafiltration and equilibrium dialysis. The binding parameter of CMPF was found to have the strongest affinity (10(7)M-1) among all the uremic toxins studied. Competitive experiment based on the method of Kragh-Hansen suggested that IA, IS and HA bind to site II, whereas CMPF binds to site I. The present limited data indicated that the four uremic toxins caused inhibition to any endo- or exogenous substances on HSA.

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Year: 1995 PMID： 8787801 DOI： 10.1248/bpb.18.1755

Source DB: PubMed Journal: Biol Pharm Bull ISSN： 0918-6158 Impact factor: 2.233

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Cited

22 in total

1. Mode of interaction of loop diuretics with human serum albumin and characterization of binding site.

Authors: N Takamura; A Haruta; H Kodama; M Tsuruoka; K Yamasaki; A Suenaga; M Otagiri
Journal: Pharm Res Date: 1996-07 Impact factor: 4.200

2. Interaction between two dicarboxylate endogenous substances, bilirubin and an uremic toxin, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid, on human serum albumin.

Authors: Y Tsutsumi; T Maruyama; A Takadate; M Goto; H Matsunaga; M Otagiri
Journal: Pharm Res Date: 1999-06 Impact factor: 4.200

3. Differential contributions of rOat1 (Slc22a6) and rOat3 (Slc22a8) to the in vivo renal uptake of uremic toxins in rats.

Authors: Tsuneo Deguchi; Yousuke Kouno; Tetsuya Terasaki; Akira Takadate; Masaki Otagiri
Journal: Pharm Res Date: 2005-04-07 Impact factor: 4.200

4. Interaction mechanism between indoxyl sulfate, a typical uremic toxin bound to site II, and ligands bound to site I of human serum albumin.

Authors: T Sakai; K Yamasaki; T Sako; U Kragh-Hansen; A Suenaga; M Otagiri
Journal: Pharm Res Date: 2001-04 Impact factor: 4.200

5. Removal of Protein-Bound Uremic Toxins during Hemodialysis Using a Binding Competitor.

Authors: Magdalena Madero; Karla B Cano; Israel Campos; Xia Tao; Vaibhav Maheshwari; Jillian Brown; Beatriz Cornejo; Garry Handelman; Stephan Thijssen; Peter Kotanko
Journal: Clin J Am Soc Nephrol Date: 2019-02-12 Impact factor: 8.237

6. p-Cresyl sulfate and indoxyl sulfate in hemodialysis patients.

Authors: Björn K I Meijers; Henriette De Loor; Bert Bammens; Kristin Verbeke; Yves Vanrenterghem; Pieter Evenepoel
Journal: Clin J Am Soc Nephrol Date: 2009-10-15 Impact factor: 8.237

7. Increased Plasma Concentrations of Unbound SN-38, the Active Metabolite of Irinotecan, in Cancer Patients with Severe Renal Failure.

Authors: Ken-ichi Fujita; Yusuke Masuo; Hidenori Okumura; Yusuke Watanabe; Hiromichi Suzuki; Yu Sunakawa; Ken Shimada; Kaori Kawara; Yuko Akiyama; Masanori Kitamura; Munetaka Kunishima; Yasutsuna Sasaki; Yukio Kato
Journal: Pharm Res Date: 2015-09-03 Impact factor: 4.200