Immunopathogenesis and immunotherapy of psoriasis.

Overwhelming evidence exists supporting the importance of T-lymphocytes and other immunologically competent cells in the pathogenesis of psoriasis. What is still uncertain, however, is whether the keratinocyte plays an initiating role in its own hyperproliferation. Studies at the basic science level have allowed us to identify various cellular and molecular events that the immunopharmacologist can target with a variety of approaches. At present, the most selective immunosuppressant available is cyclosporine. As rapid strides are made toward further elucidation of the immunopathogenesis of psoriasis, more highly selective approaches are fast becoming a reality.