BACKGROUND: Prostaglandin synthetase inhibitors have been used to prevent the onset of premature labor. But a small number of newborn infants have been reported with premature closure of the ductus arteriosus, pulmonary hypertension and/or oliguria. POPULATION AND METHODS: Eleven neonates from seven pregnancies were admitted because they suffered from adverse effects of ketoprofen given to their mothers before delivery. The plasma ketoprofen level was measured in 6 of the neonates. RESULTS: Ten of the 11 neonates had renal dysfunction which was lethal in three; two of the 11 developed cardiopulmonary complications, lethal in one. The ketoprofen concentration in plasma was high in the first few hours of life in three patients. CONCLUSION: In the absence of precise risk factors for prognosis, repeated drug measurements in the maternal plasma before delivery and in their babies after birth could be a predictive factor.
BACKGROUND: Prostaglandin synthetase inhibitors have been used to prevent the onset of premature labor. But a small number of newborn infants have been reported with premature closure of the ductus arteriosus, pulmonary hypertension and/or oliguria. POPULATION AND METHODS: Eleven neonates from seven pregnancies were admitted because they suffered from adverse effects of ketoprofen given to their mothers before delivery. The plasma ketoprofen level was measured in 6 of the neonates. RESULTS: Ten of the 11 neonates had renal dysfunction which was lethal in three; two of the 11 developed cardiopulmonary complications, lethal in one. The ketoprofen concentration in plasma was high in the first few hours of life in three patients. CONCLUSION: In the absence of precise risk factors for prognosis, repeated drug measurements in the maternal plasma before delivery and in their babies after birth could be a predictive factor.
Authors: Monika Østensen; Munther Khamashta; Michael Lockshin; Ann Parke; Antonio Brucato; Howard Carp; Andrea Doria; Raj Rai; Pierluigi Meroni; Irene Cetin; Ronald Derksen; Ware Branch; Mario Motta; Caroline Gordon; Guillermo Ruiz-Irastorza; Arsenio Spinillo; Deborah Friedman; Rolando Cimaz; Andrew Czeizel; Jean Charles Piette; Ricard Cervera; Roger A Levy; Maurizio Clementi; Sara De Carolis; Michelle Petri; Yehuda Shoenfeld; David Faden; Guido Valesini; Angela Tincani Journal: Arthritis Res Ther Date: 2006-05-11 Impact factor: 5.156