Literature DB >> 8785489

Nuclear Overhauser effect investigation on GM1 ganglioside containing N-glycolyl-neuraminic acid (II3Neu5GcGgOse4Cer).

P Brocca1, D Acquotti, S Sonnino.   

Abstract

The conformational properties of the oligosaccharide chain of GM1 ganglioside containing N-glycolyl-neuraminic acid, beta-Gal-(1-3)-beta-GalNAc-(1-4)-[alpha-Neu5Gc-(2-3)]-beta-Gal- (1-4)1-4)-beta-Glc-(1-1)-Cer, were studied through NMR nuclear Overhauser effect investigations on the monomeric ganglioside in dimethylsulfoxide, and on mixed micelles of ganglioside and dodecylphosphocholine in water. Several interresidual contacts for the trisaccharide core -beta- GalNAc-(1-4)-[alpha-Neu5Gc-(2-3)]-beta-Gal- were found to fix the relative orientation of the three saccharides, while the glycosidic linkage of the terminal beta-Gal- was found to be quite mobile as the beta-Gal-(1-3)-beta-GalNAc- disaccharide exists in different conformations. These results are similar to those found for two GM1 gangliosides containing N-acetyl-neuraminic acid and neuraminic acid [1].

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Year:  1996        PMID： 8785489     DOI： 10.1007/bf01049680

Source DB:  PubMed          Journal:  Glycoconj J        ISSN： 0282-0080            Impact factor:   2.916


  18 in total

1.  1H-NMR study of GM2 ganglioside: evidence that an interresidue amide-carboxyl hydrogen bond contributes to stabilization of a preferred conformation.

Authors:  S B Levery
Journal:  Glycoconj J       Date:  1991-12       Impact factor: 2.916

2.  A new procedure for the extraction, purification and fractionation of brain gangliosides.

Authors:  G Tettamanti; F Bonali; S Marchesini; V Zambotti
Journal:  Biochim Biophys Acta       Date:  1973-01-19

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Authors:  L Svennerholm
Journal:  Adv Exp Med Biol       Date:  1980       Impact factor: 2.622

4.  Gel phase preference of ganglioside GM1 at low concentration in two-component, two-phase phosphatidylcholine bilayers depends upon the ceramide moiety.

Authors:  P Palestini; M Allietta; S Sonnino; G Tettamanti; T E Thompson; T W Tillack
Journal:  Biochim Biophys Acta       Date:  1995-05-04

5.  Evidence for spontaneous segregation phenomena in mixed micelles of gangliosides.

Authors:  L Cantù; M Corti; S Sonnino; G Tettamanti
Journal:  Chem Phys Lipids       Date:  1990-09       Impact factor: 3.329

6.  Gas--liquid chromatographic assay of lipid-bound sialic acids: measurement of gangliosides in brain of several species.

Authors:  R K Yu; R W Ledeen
Journal:  J Lipid Res       Date:  1970-11       Impact factor: 5.922

7.  Geometrical and conformational properties of ganglioside GalNAc-GD1a, IV4GalNAcIV3Neu5AcII3Neu5AcGgOse4Cer.

Authors:  D Acquotti; L Cantù; E Ragg; S Sonnino
Journal:  Eur J Biochem       Date:  1994-10-01

8.  Preparation of GM1 ganglioside molecular species having homogeneous fatty acid and long chain base moieties.

Authors:  S Sonnino; G Kirschner; R Ghidoni; D Acquotti; G Tettamanti
Journal:  J Lipid Res       Date:  1985-02       Impact factor: 5.922

9.  Carbohydrate dynamics at a micellar surface: GD1a headgroup transformations revealed by NMR spectroscopy.

Authors:  L Poppe; H van Halbeek; D Acquotti; S Sonnino
Journal:  Biophys J       Date:  1994-05       Impact factor: 4.033

10.  Three dimensional structure of GD1b and GD1b-monolactone gangliosides in dimethylsulphoxide: a nuclear Overhauser effect investigation supported by molecular dynamics calculations.

Authors:  D Acquotti; G Fronza; E Ragg; S Sonnino
Journal:  Chem Phys Lipids       Date:  1991-09       Impact factor: 3.329
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  6 in total

1.  Conformation of the oligosaccharide chain of G(M1) ganglioside in a carbohydrate-enriched surface.

Authors:  P Brocca; P Berthault; S Sonnino
Journal:  Biophys J       Date:  1998-01       Impact factor: 4.033

Review 2.  Deregulated sphingolipid metabolism and membrane organization in neurodegenerative disorders.

Authors:  Marco Piccinini; Federica Scandroglio; Simona Prioni; Barbara Buccinnà; Nicoletta Loberto; Massimo Aureli; Vanna Chigorno; Elisa Lupino; Giovanni DeMarco; Annarosa Lomartire; Maria Teresa Rinaudo; Sandro Sonnino; Alessandro Prinetti
Journal:  Mol Neurobiol       Date:  2010-02-03       Impact factor: 5.590

Review 3.  GM1 Ganglioside: Past Studies and Future Potential.

Authors:  Massimo Aureli; Laura Mauri; Maria Grazia Ciampa; Alessandro Prinetti; Gino Toffano; Cynthia Secchieri; Sandro Sonnino
Journal:  Mol Neurobiol       Date:  2015-03-12       Impact factor: 5.590

4.  Structural basis of GM1 ganglioside recognition by simian virus 40.

Authors:  Ursula Neu; Karin Woellner; Guenter Gauglitz; Thilo Stehle
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-19       Impact factor: 11.205

5.  Lipids and membrane lateral organization.

Authors:  Sandro Sonnino; Alessandro Prinetti
Journal:  Front Physiol       Date:  2010-11-19       Impact factor: 4.566

6.  N-glycolyl GM1 ganglioside as a receptor for simian virus 40.

Authors:  Maria A Campanero-Rhodes; Alicia Smith; Wengang Chai; Sandro Sonnino; Laura Mauri; Robert A Childs; Yibing Zhang; Helge Ewers; Ari Helenius; Anne Imberty; Ten Feizi
Journal:  J Virol       Date:  2007-09-12       Impact factor: 5.103
  6 in total

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