| Literature DB >> 8785169 |
Y Yamakawa1, Y Sugita, T Nagatani, S Takahashi, T Yamakawa, S Tanaka, S Nakamura, S Ohno, H Sekihara, K Okuda, H Nakajima.
Abstract
We have examined the levels of interleukin-6 (IL-6) in plasma and supernatants of peripheral blood mononuclear cells (PBMC) from patients with Behçet's disease and healthy controls using a sensitive enzyme-linked immunosorbent assay (ELISA). Plasma IL-6 level was not detected in any subjects. The IL-6 concentrations in culture supernatants of patients with active Behçet's disease were significantly high compared with patients with inactive disease and healthy controls. Moreover, we investigated IL-6 gene expression in cultured PBMC from patients with Behçet's disease. IL-6 gene expression was enhanced in active patients compared with inactive patients. These results show that IL-6 may play a role in the pathogenesis of Behçet's disease.Entities:
Mesh：
Substances：
Year: 1996 PMID： 8785169 DOI： 10.1016/0923-1811(95)00439-4
Source DB: PubMed Journal: J Dermatol Sci ISSN： 0923-1811 Impact factor: 4.563