Literature DB >> 8784472

Inhibitory effects of lanostane-type triterpene acids, the components of Poria cocos, on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.

T Kaminaga1, K Yasukawa, H Kanno, T Tai, Y Nunoura, M Takido.   

Abstract

Pachymic acid, 3-O-acetyl-16 alpha-hydroxytrametenolic acid, and poricoic acid B had been isolated from the sclerotium of Poria cocos Wolf. These compounds showed a strong inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice. At 0.2 mumol/mouse, these compounds markedly inhibited the promoting effect of 12-O-tetradecanoylphorbol-13-acetate (1 microgram/mouse) on skin tumor formation following initiation with 7,12-dimethylbenz[a]anthracene (50 micrograms/mouse).

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Year:  1996        PMID： 8784472     DOI： 10.1159/000227592

Source DB:  PubMed          Journal:  Oncology        ISSN： 0030-2414            Impact factor:   2.935


  11 in total

1.  Inhibitory effects of triterpenoids and sterols on human immunodeficiency virus-1 reverse transcriptase.

Authors:  T Akihisa; J Ogihara; J Kato; K Yasukawa; M Ukiya; S Yamanouchi; K Oishi
Journal:  Lipids       Date:  2001-05       Impact factor: 1.880

2.  Comparison of the effects of pachymic acid, moronic acid and hydrocortisone on the polysome loading of RNAs in lipopolysaccharide-treated THP-1 macrophages.

Authors:  Tomohito Kakegawa; Lucia Satiko Yoshida; Mariko Takada; Mari Noguchi; Ken Yasukawa; Hiromi Takano-Ohmuro
Journal:  J Nat Med       Date:  2018-11-09       Impact factor: 2.343

3.  Genome Resequencing and Transcriptome Analysis Reveal the Genetic Diversity of Wolfiporia cocos Germplasm and Genes Related to High Yield.

Authors:  Qi Wang; Bisheng Huang; Dahui Liu; Yuhuan Miao
Journal:  Curr Microbiol       Date:  2022-09-10       Impact factor: 2.343

4.  The Positive Effects of Poria cocos Extract on Quality of Sleep in Insomnia Rat Models.

Authors:  Hyeyun Kim; Injune Park; Kyunyong Park; Seohyun Park; Yeong In Kim; Byong-Gon Park
Journal:  Int J Environ Res Public Health       Date:  2022-05-29       Impact factor: 4.614

5.  Pachymic acid inhibits tumorigenesis in gallbladder carcinoma cells.

Authors:  Yueguang Chen; Peilong Lian; Yanfeng Liu; Kesen Xu
Journal:  Int J Clin Exp Med       Date:  2015-10-15

6.  Pachymic Acid Enhances Pentobarbital-Induced Sleeping Behaviors via GABAA-ergic Systems in Mice.

Authors:  Vikash Kumar Shah; Jae Joon Choi; Jin-Yi Han; Mi Kyeong Lee; Jin Tae Hong; Ki-Wan Oh
Journal:  Biomol Ther (Seoul)       Date:  2014-07       Impact factor: 4.634

Review 7.  Pharmacological profiles and therapeutic applications of pachymic acid (Review).

Authors:  Chunyong Wei; Hezhen Wang; Xun Sun; Zhixun Bai; Jing Wang; Guohui Bai; Qizheng Yao; Yingshu Xu; Lei Zhang
Journal:  Exp Ther Med       Date:  2022-07-01       Impact factor: 2.751

8.  Pachymic acid induces apoptosis via activating ROS-dependent JNK and ER stress pathways in lung cancer cells.

Authors:  Jun Ma; Jun Liu; Chunwei Lu; Dingfang Cai
Journal:  Cancer Cell Int       Date:  2015-08-05       Impact factor: 5.722

9.  De novo sequencing and transcriptome analysis of Wolfiporia cocos to reveal genes related to biosynthesis of triterpenoids.

Authors:  Shaohua Shu; Bei Chen; Mengchun Zhou; Xinmei Zhao; Haiyang Xia; Mo Wang
Journal:  PLoS One       Date:  2013-08-14       Impact factor: 3.240

10.  Cytotoxic Constituents from the Sclerotia of Poria cocos against Human Lung Adenocarcinoma Cells by Inducing Mitochondrial Apoptosis.

Authors:  Seulah Lee; Seul Lee; Hyun-Soo Roh; Seong-Soo Song; Rhim Ryoo; Changhyun Pang; Kwan-Hyuck Baek; Ki Hyun Kim
Journal:  Cells       Date:  2018-08-24       Impact factor: 6.600
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