Literature DB >> 8784267

Murine T-lymphocytes express vasoactive intestinal peptide receptor 1 (VIP-R1) mRNA.

M C Johnson1, R J McCormack, M Delgado, C Martinez, D Ganea.   

Abstract

Vasoactive intestinal peptide (VIP), a neuropeptide present in primary and secondary lymphoid organs has been previously reported to inhibit IL-2 and IL-4 production as well as the proliferation of mitogen- or antigen-stimulated T-cells. Binding studies suggested that the immunoregulatory effects of VIP are mediated through specific VIP-binding sites present on lymphocyte subpopulations. Here we report on the expression of VIP-R1 mRNA in various murine lymphocyte subpopulations. By using RT-PCR. RNase protection assay, cDNA cloning, and sequence analysis, we show that stimulated and unstimulated murine spleen cells, thymocytes. CD4+ and CD8+ T-cells express VIP-R1. The VIP-R1 fragment amplified from murine brain, thymocytes, spleen cells and CD4+ T-cells share identical nucleotide sequences, and a high degree of homology with the corresponding nonlymphoid rat and human VIP-R1 sequences. The expression of VIP-R1 in thymocytes and peripheral lymphocytes, and especially in the CD4+ T-cell subset supports the idea that VIP produced or released locally in the lymphoid microenvironment could directly affect cytokine production and proliferation of T-lymphocytes.

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Year:  1996        PMID： 8784267     DOI： 10.1016/0165-5728(96)00085-9

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  10 in total

1.  Identification of the early VIP-regulated transcriptome and its associated, interactome in resting and activated murine CD4 T cells.

Authors:  Sheri Tinnell Dorsam; Emilie Vomhof-Dekrey; Rebecca J Hermann; Jodie S Haring; Travis Van der Steen; Erich Wilkerson; Goran Boskovic; James Denvir; Yulia Dementieva; Donald Primerano; Glenn Paul Dorsam
Journal:  Mol Immunol       Date:  2010-02-01       Impact factor: 4.407

Review 2.  The mucosal immune system: master regulator of bidirectional gut-brain communications.

Authors:  Nick Powell; Marjorie M Walker; Nicholas J Talley
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2017-01-18       Impact factor: 46.802

3.  Impairment of mossy fiber long-term potentiation and associative learning in pituitary adenylate cyclase activating polypeptide type I receptor-deficient mice.

Authors:  C Otto; Y Kovalchuk; D P Wolfer; P Gass; M Martin; W Zuschratter; H J Gröne; C Kellendonk; F Tronche; R Maldonado; H P Lipp; A Konnerth; G Schütz
Journal:  J Neurosci       Date:  2001-08-01       Impact factor: 6.167

4.  Vasoactive intestinal peptide signaling axis in human leukemia.

Authors:  Glenn Paul Dorsam; Keith Benton; Jarrett Failing; Sandeep Batra
Journal:  World J Biol Chem       Date:  2011-06-26

5.  Expression and fine mapping of murine vasoactive intestinal peptide receptor 1.

Authors:  B Karacay; M S O'Dorisio; K Kasow; C Hollenback; R Krahe
Journal:  J Mol Neurosci       Date:  2001-12       Impact factor: 3.444

6.  Vasoactive intestinal peptide receptor 1 is downregulated during expansion of antigen-specific CD8 T cells following primary and secondary Listeria monocytogenes infections.

Authors:  Emilie E Vomhof-DeKrey; Jodie S Haring; Glenn P Dorsam
Journal:  J Neuroimmunol       Date:  2011-03-10       Impact factor: 3.478

7.  Human IgA-inducing protein from dendritic cells induces IgA production by naive IgD+ B cells.

Authors:  Mark A Endsley; Leo M Njongmeta; Elisabeth Shell; Matthew W Ryan; Alexander J Indrikovs; Seckin Ulualp; Randall M Goldblum; Waithaka Mwangi; D Mark Estes
Journal:  J Immunol       Date:  2009-02-15       Impact factor: 5.422

8.  Stimulatory and suppressive signal transduction regulates vasoactive intestinal peptide receptor-1 (VPAC-1) in primary mouse CD4 T cells.

Authors:  Emilie E Vomhof-DeKrey; Glenn Paul Dorsam
Journal:  Brain Behav Immun       Date:  2008-06-13       Impact factor: 7.217

Review 9.  Neuroendocrine cells derived chemokine vasoactive intestinal polypeptide (VIP) in allergic diseases.

Authors:  Alok K Verma; Murli Manohar; Sathisha Upparahalli Venkateshaiah; Anil Mishra
Journal:  Cytokine Growth Factor Rev       Date:  2017-09-23       Impact factor: 7.638

10.  A transcriptionally permissive epigenetic landscape at the vasoactive intestinal peptide receptor-1 promoter suggests a euchromatin nuclear position in murine CD4 T cells.

Authors:  K D Benton; R J Hermann; E E Vomhof-DeKrey; J S Haring; T Van der Steen; J Smith; S Dovat; G P Dorsam
Journal:  Regul Pept       Date:  2009-09-01
  10 in total

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