Literature DB >> 8783838

Steroidal saponins from Nolina recurvata stems and their inhibitory activity on cyclic AMP phosphodiesterase.

Y Mimaki1, Y Takaashi, M Kuroda, Y Sashida, T Nikaido.   

Abstract

Seven steroidal saponins were isolated from the stems of Nolina recurvata, five of which appeared to be new compounds and were assigned as spirosta-5,25(27)-diene-1 beta,3 beta-diol (neoruscogenin) 1-O--O-alpha-L-rhamnopyranosyl-(1--> 2)-O-[beta-D-xylopyranosyl-(1-->3)]-alpha-L-arabinopyranoside-, (25S)-spirost-5-ene-1 beta,3 beta-diol [(25S)-ruscogenin] 1-O-{O-alpha-L-rhamnopyranosyl-(1-->2)-O-[beta-D-xylopyranosyl-(1--> 3)]-alpha-L-arabinopyranoside}, neoruscogenin 1-O-{O-alpha-L-rhamnopyranosyl-(1-->2)-O-[beta-D-xylopyranosyl-(1--> 3)]-beta-D-fucopyranoside}, 26-O-beta-D-glucopyranosyl-22-O-methylfurosta-5,25(27)-diene-1 beta,3 beta,22 xi,26-tetrol 1-O--O-alpha-L-rhamnopyranosyl-(1--> 2)-O-[beta-D-xylopyranosyl-(1-->3)]-alpha-L-arabinopyranoside- and 26-O-beta-D-glucopyranosylfurosta-5,20(22),25(27)-triene-1 beta,3 beta,26-triol 1-O-{O-alpha-L-rhamnopyranosyl-(1--> 2)-alpha-L-arabinopyranoside}. The isolated saponins were evaluated for their inhibitory activity on cyclic AMP phosphodiesterase to identify new compounds with medicinal potential.

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Year:  1996        PMID: 8783838     DOI: 10.1016/0031-9422(96)00107-0

Source DB:  PubMed          Journal:  Phytochemistry        ISSN: 0031-9422            Impact factor:   4.072


  3 in total

1.  Steroidal saponins from fresh stems of Dracaena angustifolia.

Authors:  Min Xu; Ying-Jun Zhang; Xing-Cong Li; Melissa R Jacob; Chong-Ren Yang
Journal:  J Nat Prod       Date:  2010-09-24       Impact factor: 4.050

2.  Synergistic combination of DT-13 and topotecan inhibits human gastric cancer via myosin IIA-induced endocytosis of EGF receptor in vitro and in vivo.

Authors:  Xiao-Wen Yu; Sensen Lin; Hong-Zhi Du; Ren-Ping Zhao; Shu-Yun Feng; Bo-Yang Yu; Lu-Yong Zhang; Rui-Ming Li; Chang-Min Qian; Xue-Jun Luo; Sheng-Tao Yuan; Li Sun
Journal:  Oncotarget       Date:  2016-05-31

3.  Novel steroidal components from the underground parts of Ruscus aculeatus L.

Authors:  Simona De Marino; Carmen Festa; Franco Zollo; Maria Iorizzi
Journal:  Molecules       Date:  2012-11-26       Impact factor: 4.411

  3 in total

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