OBJECTIVE: Evaluate antibiotic-associated diarrhea and toxigenic Clostridium difficile in stool specimens obtained from children before and after 10 days of amoxicillin/clavulanate for otitis media. DESIGN: Children, 12 to 47 months of age, treated with amoxicillin/clavulanate for otitis media in an outpatient setting were enrolled. Stool specimens were obtained at enrollment, when diarrhea occurred and at the end of therapy. All stool specimens were tested for C. difficile toxins A and B by enzyme immunoassay. RESULTS: Seventy-six children who had stool specimens collected at enrollment and after therapy were included in the analysis. None had C. difficile toxin in stool specimens at enrollment. Six (27%) of 22 children with diarrhea, and 4 (7%) of 54 children without diarrhea had C. difficile toxin present at completion of therapy (P = 0.03). CONCLUSION: Toxigenic C. difficile was identified in 13% of children at the conclusion of amoxicillin/clavulanate therapy with a significantly higher frequency in children with diarrhea.
OBJECTIVE: Evaluate antibiotic-associated diarrhea and toxigenic Clostridium difficile in stool specimens obtained from children before and after 10 days of amoxicillin/clavulanate for otitis media. DESIGN:Children, 12 to 47 months of age, treated with amoxicillin/clavulanate for otitis media in an outpatient setting were enrolled. Stool specimens were obtained at enrollment, when diarrhea occurred and at the end of therapy. All stool specimens were tested for C. difficile toxins A and B by enzyme immunoassay. RESULTS: Seventy-six children who had stool specimens collected at enrollment and after therapy were included in the analysis. None had C. difficile toxin in stool specimens at enrollment. Six (27%) of 22 children with diarrhea, and 4 (7%) of 54 children without diarrhea had C. difficile toxin present at completion of therapy (P = 0.03). CONCLUSION: Toxigenic C. difficile was identified in 13% of children at the conclusion of amoxicillin/clavulanate therapy with a significantly higher frequency in children with diarrhea.
Authors: Daniel Merenstein; Claire M Fraser; Robert F Roberts; Tian Liu; Silvia Grant-Beurmann; Tina P Tan; Keisha Herbin Smith; Tom Cronin; Olivia A Martin; Mary Ellen Sanders; Sean C Lucan; Maureen A Kane Journal: Nutrients Date: 2021-08-17 Impact factor: 6.706
Authors: V Sathyendran; G N McAuliffe; T Swager; J T Freeman; S L Taylor; S A Roberts Journal: Eur J Clin Microbiol Infect Dis Date: 2014-05-09 Impact factor: 3.267
Authors: Melanie Werner; Jan S Suchodolski; Reinhard K Straubinger; Georg Wolf; Jörg M Steiner; Jonathan A Lidbury; Felix Neuerer; Katrin Hartmann; Stefan Unterer Journal: J Vet Intern Med Date: 2020-04-23 Impact factor: 3.333