Development of dopamine receptors in the forebrain of the domestic chick in relation to auditory imprinting. An autoradiographic study.

The rostro-medial neostriatum/hyperstriatum ventrale (MNH) and the neostriatum dorsocaudale (Ndc) are forebrain regions which play a role in auditory filial imprinting. Both regions receive a distinct dopaminergic input from the mesencephalon and we were interested to investigate if the dopaminergic system, which is known to play a role in associative learning processes and neuronal plasticity is involved in auditory imprinting. Using ligand autoradiography we studied the distribution and density of dopamine receptors (D1 and D2 type) in the forebrain of socially isolated chicks during the first postnatal week and compared these data with the values of age-matched imprinted chicks. D1- and D2-receptors were present in the chick forebrain on the day of hatching and they showed in general, the same distribution until postnatal day 7. Between days 0 and 2 the D2-receptor density increased significantly in the lobus parolfactorius and paleostriatum augmentatum while for D1-receptor density no significant changes were detectable. The receptor densities in the investigated forebrain regions did not differ significantly between imprinted and control chicks. These results suggest that auditory imprinting does not induce alterations of dopamine receptor density, however, more subtle changes can not be excluded. The presented detailed data about the developmental profile of dopamine receptors within distinct brain regions is a further step towards a more specific interpretation of behavioral effects of dopamine receptor agonists or antagonists at different postnatal ages.