Literature DB >> 8782886

Expression of mRNA coding for the serotonin transporter in aged vs. young rat brain: differential effects of glucocorticoids.

F Fumagalli1, S R Jones, M G Caron, F J Seidler, T A Slotkin.   

Abstract

Serotonin transporter mRNA expression in midbrain of young and aged rats was measured after long-term infusion of dexamethasone (0.01 and 0.05 mg/kg/day). Aging alone had no effect. Dexamethasone significantly decreased expression in both young and old rats but the effect was greater in the aged group. Adrenocortical dysregulation is common in elderly depression; our results suggest that glucocorticoids interact with aging to exacerbate abnormalities of serotonergic function, contributing to reduced antidepressant effectiveness.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8782886     DOI： 10.1016/0006-8993(96)00119-9

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  5 in total

1.  Platelet monoamine oxidase-A activity and aging: effect of carnosine.

Authors:  S Banerjee; M K Poddar
Journal:  J Physiol Sci       Date:  2013-05-09       Impact factor: 2.781

2.  Short-term fluoxetine treatment induces neuroendocrine and behavioral anxiogenic-like responses in adolescent male rats.

Authors:  Francisca Gomez; César Venero; María-Paz Viveros; Luis García-García
Journal:  Exp Brain Res       Date:  2014-12-17       Impact factor: 1.972

3.  The pro-inflammatory cytokine TNF-α regulates the activity and expression of the serotonin transporter (SERT) in astrocytes.

Authors:  Sandra Malynn; Antonio Campos-Torres; Paul Moynagh; Jana Haase
Journal:  Neurochem Res       Date:  2013-01-22       Impact factor: 3.996

4.  Role of dopamine transporter in methamphetamine-induced neurotoxicity: evidence from mice lacking the transporter.

Authors:  F Fumagalli; R R Gainetdinov; K J Valenzano; M G Caron
Journal:  J Neurosci       Date:  1998-07-01       Impact factor: 6.167

5.  Combinatorial interaction between two human serotonin transporter gene variable number tandem repeats and their regulation by CTCF.

Authors:  Fahad R Ali; Sylvia A Vasiliou; Kate Haddley; Ursula M Paredes; Julian C Roberts; Fabio Miyajima; Elena Klenova; Vivien J Bubb; John P Quinn
Journal:  J Neurochem       Date:  2009-10-26       Impact factor: 5.372
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.