| Literature DB >> 8782650 |
N Mandahl1, M Akerman, P Aman, P Dal Cin, I De Wever, C D Fletcher, F Mertens, F Mitelman, J Rosai, A Rydholm, R Sciot, G Tallini, H Van den Berghe, W Van de Ven, R Vanni, H Willén.
Abstract
Ordinary lipomas are cytogenetically characterized by a variety of balanced rearrangements involving chromosome segment 12ql3-15, and atypical lipomatous tumors (ALT) by supernumerary ring chromosomes or giant markers known to contain amplified 12q sequences. In a series of 228 cytogenetically analyzed and histopathologically reexamined ordinary lipomas and ALT, 10 tumors showed unbalanced chromosome-12 aberrations. All 4 tumors with loss of segments from 12q were classified as ordinary lipomas, whereas 5 of the 6 tumors showing gain of 12q material were diagnosed as ALT. One or three extra copies of 12q15-q24 were present in all 5 ALT. We conclude that duplication of 12q sequences may be a sufficient level of amplification for development of the microscopic appearance that characterizes ALT.Entities:
Mesh：
Year: 1996 PMID： 8782650 DOI： 10.1002/(SICI)1097-0215(19960904)67:5<632::AID-IJC7>3.0.CO;2-V
Source DB: PubMed Journal: Int J Cancer ISSN： 0020-7136 Impact factor: 7.396