Literature DB >> 8782226

Proton irradiation of [18O]O2: production of [18F]F2 and [18F]F2 + [18F] OF2.

A Bishop1, N Satyamurthy, G Bida, G Hendry, M Phelps, J R Barrio.   

Abstract

The production of 18F electrophilic reagents via the 18O(p,n)18F reaction has been investigated in small-volume target bodies made of aluminum, copper, gold-plated copper and nickel, having straight or conical bore shapes. Three irradiation protocols-single-step, two-step and modified two-step-were used for the recovery of the 18F activity. The single-step irradiation protocol was tested in all the target bodies. Based on the single-step performance, aluminum targets were utilized extensively in the investigation of the two-step and modified two-step irradiation protocols. With an 11-MeV cyclotron and using the two-step irradiation protocol, > 1Ci [18F]F2 was recovered reproducibly from an aluminum target body. Probable radical mechanisms for the formation of OF2 and FONO2 (fluorine nitrate) in the single-step and modified two-step targets are proposed based on the amount of ozone generated and the nitrogen impurity present in the target gases, respectively.

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Year:  1996        PMID： 8782226     DOI： 10.1016/0969-8051(95)02037-3

Source DB:  PubMed          Journal:  Nucl Med Biol        ISSN： 0969-8051            Impact factor:   2.408


  10 in total

1.  Treatment response evaluation using 18F-FDOPA PET in patients with recurrent malignant glioma on bevacizumab therapy.

Authors:  Johannes Schwarzenberg; Johannes Czernin; Timothy F Cloughesy; Benjamin M Ellingson; Whitney B Pope; Tristan Grogan; David Elashoff; Cheri Geist; Daniel H S Silverman; Michael E Phelps; Wei Chen
Journal:  Clin Cancer Res       Date:  2014-03-31       Impact factor: 12.531

2.  Rate of change in maximum 18F-FDOPA PET uptake and non-enhancing tumor volume predict malignant transformation and overall survival in low-grade gliomas.

Authors:  Talia C Oughourlian; Jingwen Yao; Jacob Schlossman; Catalina Raymond; Matthew Ji; Hiroyuki Tatekawa; Noriko Salamon; Whitney B Pope; Johannes Czernin; Phioanh L Nghiemphu; Albert Lai; Timothy F Cloughesy; Benjamin M Ellingson
Journal:  J Neurooncol       Date:  2020-01-24       Impact factor: 4.130

3.  18F-FDOPA and 18F-FLT positron emission tomography parametric response maps predict response in recurrent malignant gliomas treated with bevacizumab.

Authors:  Robert J Harris; Timothy F Cloughesy; Whitney B Pope; Phioanh L Nghiemphu; Albert Lai; Taryar Zaw; Johannes Czernin; Michael E Phelps; Wei Chen; Benjamin M Ellingson
Journal:  Neuro Oncol       Date:  2012-06-18       Impact factor: 12.300

4.  Multiparametric MR-PET measurements in hypermetabolic regions reflect differences in molecular status and tumor grade in treatment-naïve diffuse gliomas.

Authors:  Hiroyuki Tatekawa; Akifumi Hagiwara; Hiroyuki Uetani; Jingwen Yao; Talia C Oughourlian; Shadfar Bahri; Chencai Wang; Catalina Raymond; Albert Lai; Timothy F Cloughesy; Phioanh L Nghiemphu; Linda M Liau; Whitney B Pope; Noriko Salamon; Benjamin M Ellingson
Journal:  J Neurooncol       Date:  2020-09-14       Impact factor: 4.130

5.  Preferential tumor localization in relation to 18F-FDOPA uptake for lower-grade gliomas.

Authors:  Hiroyuki Tatekawa; Hiroyuki Uetani; Akifumi Hagiwara; Jingwen Yao; Talia C Oughourlian; Issei Ueda; Catalina Raymond; Albert Lai; Timothy F Cloughesy; Phioanh L Nghiemphu; Linda M Liau; Shadfar Bahri; Whitney B Pope; Noriko Salamon; Benjamin M Ellingson
Journal:  J Neurooncol       Date:  2021-03-11       Impact factor: 4.130

6.  Maximum Uptake and Hypermetabolic Volume of 18F-FDOPA PET Estimate Molecular Status and Overall Survival in Low-Grade Gliomas: A PET and MRI Study.

Authors:  Hiroyuki Tatekawa; Jingwen Yao; Talia C Oughourlian; Akifumi Hagiwara; Chencai Wang; Catalina Raymond; Albert Lai; Timothy F Cloughesy; Phioanh L Nghiemphu; Linda M Liau; Noriko Salamon; Benjamin M Ellingson
Journal:  Clin Nucl Med       Date:  2020-12       Impact factor: 10.782

7.  Improved Stability and Practicality for Synthesis of 4-Borono-2-[18F]fluoro-l-phenylalanine by Combination of [18O]O2 Single-Use and [18F]CH3COOF Labeling Agents.

Authors:  Sadahiro Naka; Toshimitsu Watanabe; Yasukazu Kanai; Tadashi Watabe; Mitsuaki Tatsumi; Hiroki Kato; Eku Shimosegawa; Jun Hatazawa
Journal:  Nucl Med Mol Imaging       Date:  2022-02-08

8.  Worse prognosis for IDH wild-type diffuse gliomas with larger residual biological tumor burden.

Authors:  Hiroyuki Tatekawa; Hiroyuki Uetani; Akifumi Hagiwara; Shadfar Bahri; Catalina Raymond; Albert Lai; Timothy F Cloughesy; Phioanh L Nghiemphu; Linda M Liau; Whitney B Pope; Noriko Salamon; Benjamin M Ellingson
Journal:  Ann Nucl Med       Date:  2021-06-14       Impact factor: 2.668

9.  Differentiating IDH status in human gliomas using machine learning and multiparametric MR/PET.

Authors:  Hiroyuki Tatekawa; Akifumi Hagiwara; Hiroyuki Uetani; Shadfar Bahri; Catalina Raymond; Albert Lai; Timothy F Cloughesy; Phioanh L Nghiemphu; Linda M Liau; Whitney B Pope; Noriko Salamon; Benjamin M Ellingson
Journal:  Cancer Imaging       Date:  2021-03-10       Impact factor: 3.909

Review 10.  Closing the gap between 19F and 18F chemistry.

Authors:  Javier Ajenjo; Gianluca Destro; Bart Cornelissen; Véronique Gouverneur
Journal:  EJNMMI Radiopharm Chem       Date:  2021-09-25
  10 in total

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