Literature DB >> 8781967

Stage-specific expression of fuco-neolacto- (Lewis X) and ganglio-series neutral glycosphingolipids during brain development: characterization of Lewis X and related glycosphingolipids in bovine, human and rat brain.

S Dasgupta1, E L Hogan, S S Spicer.   

Abstract

We have purified and characterized a bovine brain pentaglycosylceramide as Lewis X and identified it in human and rat brain using anti-Lewis X (anti-SSEA 1) monoclonal antibody. Neutral glycosphingolipid expression in developing rat brain has been examined by digoxigenin immunostaining and TLC-immunostaining using anti-SSEA 1 and anti-GgOse4Cer (GA1) monoclonal antibodies. Five transient Lewis X-series bands were identified in brain at embryonic day 15 that disappear by postnatal day 5 (one disappears at embryonic day 18). Gangliotetraosylceramide (GA1) first appears at embryonic day 21 and increases in concentration with age until postnatal day 21. In addition, we have purified another minor brain neutral glycosphingolipid and tentatively identified it as a Lewis X-series glycolipid by gas chromatography-mass spectrometry analysis followed by TLC-immunostaining with anti-SSEA 1 antibody.

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Year:  1996        PMID： 8781967     DOI： 10.1007/bf00731469

Source DB:  PubMed          Journal:  Glycoconj J        ISSN： 0282-0080            Impact factor:   2.916


  37 in total

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Journal:  Ann Neurol       Date:  1990       Impact factor: 10.422

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Journal:  Brain Res       Date:  1985-05-13       Impact factor: 3.252

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Journal:  J Biol Chem       Date:  1992-03-15       Impact factor: 5.157

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Journal:  J Neurochem       Date:  1988-06       Impact factor: 5.372

9.  The blood group I antigen defined by monoclonal antibody C6 is a marker of early mesoderm during murine embryogenesis.

Authors:  B A Fenderson; E M Eddy; S Hakomori
Journal:  Differentiation       Date:  1988-07       Impact factor: 3.880

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Authors:  M Igarashi; H Waki; S Saito; Y Komiya; S Ando
Journal:  Brain Res Dev Brain Res       Date:  1994-03-18
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  5 in total

1.  Development and characterization of a specific IgG monoclonal antibody toward the Lewis x antigen using splenocytes of Schistosoma mansoni-infected mice.

Authors:  Msano Mandalasi; Nelum Dorabawila; David F Smith; Jamie Heimburg-Molinaro; Richard D Cummings; A Kwame Nyame
Journal:  Glycobiology       Date:  2013-03-29       Impact factor: 4.313

2.  The distribution of the proteoglycan FORSE-1 in the developing mouse central nervous system.

Authors:  Albert Kelly; Aisling O'Malley; Mohammad Redha; Gerard W O'Keeffe; Denis S Barry
Journal:  J Anat       Date:  2018-11-25       Impact factor: 2.610

3.  Novel myelin penta- and hexa-acetyl-galactosyl-ceramides: structural characterization and immunoreactivity in cerebrospinal fluid.

Authors:  Maria Podbielska; Somsankar Dasgupta; Steven B Levery; Wallace W Tourtellotte; Heidi Annuk; Anthony P Moran; Edward L Hogan
Journal:  J Lipid Res       Date:  2010-02-12       Impact factor: 5.922

4.  alpha1,3 Fucosyltransferase, alpha-L-fucosidase, alpha-D-galactosidase, beta-D-galactosidase, and Le(x) glycoconjugates in developing rat brain.

Authors:  G Y Wiederschain; O Koul; J M Aucoin; F I Smith; R H McCluer
Journal:  Glycoconj J       Date:  1998-04       Impact factor: 2.916

5.  Regulation of glycan structures in murine embryonic stem cells: combined transcript profiling of glycan-related genes and glycan structural analysis.

Authors:  Alison V Nairn; Kazuhiro Aoki; Mitche dela Rosa; Mindy Porterfield; Jae-Min Lim; Michael Kulik; J Michael Pierce; Lance Wells; Stephen Dalton; Michael Tiemeyer; Kelley W Moremen
Journal:  J Biol Chem       Date:  2012-09-17       Impact factor: 5.157
  5 in total

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