Literature DB >> 8781237

Neurogenic amplification of immune complex inflammation.

C R Bozic1, B Lu, U E Höpken, C Gerard, N P Gerard.   

Abstract

The formation of intrapulmonary immune complexes in mice generates a vigorous inflammatory response characterized by microvascular permeability and polymorphonuclear neutrophil influx. Gene-targeted disruption of the substance P receptor (NK-1R) protected the lung from immune complex injury, as did disruption of the C5a anaphylatoxin receptor. Immunoreactive substance P was measurable in fluids lining the lung at time points before neutrophil influx and may thus be involved in an early step in the inflammatory response to immune complexes in the lung.

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Year:  1996        PMID： 8781237     DOI： 10.1126/science.273.5282.1722

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  78 in total

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