Literature DB >> 8781233

Small-conductance, calcium-activated potassium channels from mammalian brain.

M Köhler1, B Hirschberg, C T Bond, J M Kinzie, N V Marrion, J Maylie, J P Adelman.   

Abstract

Members of a previously unidentified family of potassium channel subunits were cloned from rat and human brain. The messenger RNAs encoding these subunits were widely expressed in brain with distinct yet overlapping patterns, as well as in several peripheral tissues. Expression of the messenger RNAs in Xenopus oocytes resulted in calcium-activated, voltage-independent potassium channels. The channels that formed from the various subunits displayed differential sensitivity to apamin and tubocurare. The distribution, function, and pharmacology of these channels are consistent with the SK class of small-conductance, calcium-activated potassium channels, which contribute to the afterhyperpolarization in central neurons and other cell types.

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Year:  1996        PMID： 8781233     DOI： 10.1126/science.273.5282.1709

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  307 in total

1.  Gating properties of single SK channels in hippocampal CA1 pyramidal neurons.

Authors:  B Hirschberg; J Maylie; J P Adelman; N V Marrion
Journal:  Biophys J       Date:  1999-10       Impact factor: 4.033

2.  Inwardly rectifying current-voltage relationship of small-conductance Ca2+-activated K+ channels rendered by intracellular divalent cation blockade.

Authors:  H Soh; C S Park
Journal:  Biophys J       Date:  2001-05       Impact factor: 4.033

3.  Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells.

Authors:  D Strøbaek; T D Jørgensen; P Christophersen; P K Ahring; S P Olesen
Journal:  Br J Pharmacol       Date:  2000-03       Impact factor: 8.739

4.  Small conductance Ca2+-activated K+ channels are regulated by Ca2+-calmodulin-dependent protein kinase II in murine colonic myocytes.

Authors:  I D Kong; S D Koh; O Bayguinov; K M Sanders
Journal:  J Physiol       Date:  2000-04-15       Impact factor: 5.182

5.  Effects of inhibitors of small- and intermediate-conductance calcium-activated potassium channels, inwardly-rectifying potassium channels and Na(+)/K(+) ATPase on EDHF relaxations in the rat hepatic artery.

Authors:  D A Andersson; P M Zygmunt; P Movahed; T L Andersson; E D Högestätt
Journal:  Br J Pharmacol       Date:  2000-04       Impact factor: 8.739

6.  Novel action of BAPTA series chelators on intrinsic K+ currents in rat hippocampal neurones.

Authors:  B Lancaster; A M Batchelor
Journal:  J Physiol       Date:  2000-01-15       Impact factor: 5.182

7.  An apamin-sensitive Ca2+-activated K+ current in hippocampal pyramidal neurons.

Authors:  M Stocker; M Krause; P Pedarzani
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-13       Impact factor: 11.205

8.  Photolytic manipulation of [Ca2+]i reveals slow kinetics of potassium channels underlying the afterhyperpolarization in hippocampal pyramidal neurons.

Authors:  P Sah; J D Clements
Journal:  J Neurosci       Date:  1999-05-15       Impact factor: 6.167

9.  Cholinergic inhibition of ventral midbrain dopamine neurons.

Authors:  C D Fiorillo; J T Williams
Journal:  J Neurosci       Date:  2000-10-15       Impact factor: 6.167

10.  TEA- and apamin-resistant K(Ca) channels in guinea-pig myenteric neurons: slow AHP channels.

Authors:  Fivos Vogalis; John R Harvey; John B Furness
Journal:  J Physiol       Date:  2002-01-15       Impact factor: 5.182
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