Literature DB >> 8780729

Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM.

T Takeshita1, T Arita, H Asao, N Tanaka, M Higuchi, H Kuroda, K Kaneko, H Munakata, Y Endo, T Fujita, K Sugamura.   

Abstract

We molecularly cloned a cDNA coding for a novel phosphotyrosine molecule with a 70 kDa molecular mass, named STAM (signal transducing adaptor molecule), which is tyrosine-phosphorylated rapidly after stimulation with various cytokines such as IL-2, IL-3, IL-4, IL-7, GM-CSF, EGF and PDGF. STAM contains an SH3 (Src-homology 3) domain and the ITAM (immunoreceptor tyrosine-based activation motif), suggesting that STAM acts as an adaptor molecule involved in signal transducing pathways from the cytokine receptors.

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Year:  1996        PMID： 8780729     DOI： 10.1006/bbrc.1996.1290

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  20 in total

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