| Literature DB >> 8778244 |
E L Meneses da Silva1, F Roblot, J Mahuteau, A Cavé.
Abstract
A new Annonaceous acetogenin, coriadienin (1), has been isolated from the roots of Annona coriacea Mart. (Annonaceae). This structure is the first reported acetogenin containing two double bonds. Compound 1 showed potent cytotoxicity against VERO and KB cell lines. Compound 1 appears to play an important role in the biosynthetic pathway of mono- and bis-THF acetogenins, and it is proposed as a biogenetic precursor of coriacin. A known cytotoxic acetogenin, gigantetronenin, was also isolated from this plant.Entities:
Mesh：
Substances：
Year: 1996 PMID： 8778244 DOI： 10.1021/np960079e
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050