Literature DB >> 8778243

Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase.

H D Sun1, S X Qiu, L Z Lin, Z Y Wang, Z W Lin, T Pengsuparp, J M Pezzuto, H H Fong, G A Cordell, N R Farnsworth.   

Abstract

An A ring-secocycloartene triterpenoid, nigranoic acid (3,4-secocycloarta-4(28),24-(Z)-diene-3,-26-dioic acid, (1) was isolated from the stems of Schisandra sphaerandra, a Chinese traditional medicinal plant. Its structure elucidation and unambiguous NMR spectral assignment were achieved by the combination of 1D- and 2D-NMR techniques with the aid of computer modeling. Nigranoic acid showed activity in several anti-HIV reverse transcriptase and polymerase assays.

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Year:  1996        PMID： 8778243     DOI： 10.1021/np960149h

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  17 in total

Review 1.  Plant products as antimicrobial agents.

Authors:  M M Cowan
Journal:  Clin Microbiol Rev       Date:  1999-10       Impact factor: 26.132

Review 2.  Molecular mechanism of adenomatous polyposis coli-induced blockade of base excision repair pathway in colorectal carcinogenesis.

Authors:  Satya Narayan; Ritika Sharma
Journal:  Life Sci       Date:  2015-09-01       Impact factor: 5.037

3.  Inhibitory effects of triterpenoids and sterols on human immunodeficiency virus-1 reverse transcriptase.

Authors:  T Akihisa; J Ogihara; J Kato; K Yasukawa; M Ukiya; S Yamanouchi; K Oishi
Journal:  Lipids       Date:  2001-05       Impact factor: 1.880

4.  From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors.

Authors:  Lijia Xu; Nicole Grandi; Claudia Del Vecchio; Daniela Mandas; Angela Corona; Dario Piano; Francesca Esposito; Cristina Parolin; Enzo Tramontano
Journal:  J Microbiol       Date:  2015-03-04       Impact factor: 3.422

5.  Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase.

Authors:  Robert J Visalli; Hannah Ziobrowski; Kameswara R Badri; Johnny J He; Xiugen Zhang; Sri Ranjini Arumugam; Hua Zhao
Journal:  Bioorg Med Chem Lett       Date:  2015-06-06       Impact factor: 2.823

6.  Antituberculosis cycloartane triterpenoids from Radermachera boniana.

Authors:  Ngan B Truong; Cuong V Pham; Huong T M Doan; Hung V Nguyen; Cuong M Nguyen; Hiep T Nguyen; Hong-jie Zhang; Harry H S Fong; Scott G Franzblau; Djaja D Soejarto; Minh V Chau
Journal:  J Nat Prod       Date:  2011-04-06       Impact factor: 4.050

7.  A role for a menthone reductase in resistance against microbial pathogens in plants.

Authors:  Hyong Woo Choi; Byung Gil Lee; Nak Hyun Kim; Yong Park; Chae Woo Lim; Hyun Kyu Song; Byung Kook Hwang
Journal:  Plant Physiol       Date:  2008-07-03       Impact factor: 8.340

8.  Antimicrobial Effects of a Lipophilic Fraction and Kaurenoic Acid Isolated from the Root Bark Extracts of Annona senegalensis.

Authors:  Theophine Chinwuba Okoye; Peter Achunike Akah; Charles Ogbonnaya Okoli; Adaobi Chioma Ezike; Edwin Ogechukwu Omeje; Uchenna Estella Odoh
Journal:  Evid Based Complement Alternat Med       Date:  2012-05-24       Impact factor: 2.629

9.  Two New 3,4;9,10-seco-Cycloartane Type Triterpenoids from Illicium difengpi and Their Anti-Inflammatory Activities.

Authors:  Chuntong Li; Fengmin Xi; Junling Mi; Zhijun Wu; Wansheng Chen
Journal:  Evid Based Complement Alternat Med       Date:  2013-05-15       Impact factor: 2.629

10.  Inhibitory effect of essential oils obtained from plants grown in Colombia on yellow fever virus replication in vitro.

Authors:  Rocío Meneses; Raquel E Ocazionez; Jairo R Martínez; Elena E Stashenko
Journal:  Ann Clin Microbiol Antimicrob       Date:  2009-03-06       Impact factor: 3.944
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