Literature DB >> 877583

DNA strand scission by benzo[a]pyrene diol epoxides.

H B Gamper, A S Tung, K Straub, J C Bartholomew, M Calvin.   

Abstract

Syn-and anti-benzo[a]pyrene diol epoxides elicit a concentration-dependent nicking of superhelical Col E1 DNA in an in vitro reaction monitored by agarose gel electrophoresis and electron microscopy. This strand scission represents less than 1 percent of the DNA modification by diol epoxide. Kinetic analysis implicates the formation of unstable phosphotriesters, hydrolysis of which nick the DNA.

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Year:  1977        PMID： 877583     DOI： 10.1126/science.877583

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  9 in total

Review 1.  Nucleic acid adducts of chemical carcinogens and mutagens.

Authors:  K Hemminki
Journal:  Arch Toxicol       Date:  1983-04       Impact factor: 5.153

2.  Carcinogenic epoxides of benzo[a]pyrene and cyclopenta[cd]pyrene induce base substitutions via specific transversions.

Authors:  E Eisenstadt; A J Warren; J Porter; D Atkins; J H Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

3.  Cyclopenta[c,d]pyrene: a highly mutagenic polycyclic aromatic hydrocarbon.

Authors:  E Eisenstadt; A Gold
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

4.  DFT investigations of phosphotriesters hydrolysis in aqueous solution: a model for DNA single strand scission induced by N-nitrosoureas.

Authors:  Tingting Liu; Lijiao Zhao; Rugang Zhong
Journal:  J Mol Model       Date:  2012-09-22       Impact factor: 1.810

5.  DNA alkylation and unwinding induced by benzo[a]pyrene diol epoxide: modulation by ionic strength and superhelicity.

Authors:  H B Gamper; K Straub; M Calvin; J C Bartholomew
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205

6.  Modification of DNA by the benzo[a]pyrene metabolite diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene.

Authors:  T Kakefuda; H Yamamoto
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205

7.  Identification of the major adducts formed by reaction of benzo(a)pyrene diol epoxide with DNA in vitro.

Authors:  K M Straub; T Meehan; A L Burlingame; M Calvin
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

8.  Effect of PARP-1 deficiency on DNA damage and repair in human bronchial epithelial cells exposed to Benzo(a)pyrene.

Authors:  Gong-Hua Tao; Lin-Qing Yang; Chun-Mei Gong; Hai-Yan Huang; Jian-Dong Liu; Jian-Jun Liu; Jian-Hui Yuan; Wen Chen; Zhi-Xiong Zhuang
Journal:  Mol Biol Rep       Date:  2009-02-27       Impact factor: 2.316

9.  Detection of phosphodiester adducts formed by the reaction of benzo[a]pyrene diol epoxide with 2'-deoxynucleotides using collision-induced dissociation electrospray ionization tandem mass spectrometry.

Authors:  Margaret Gaskell; Balvinder Kaur; Peter B Farmer; Rajinder Singh
Journal:  Nucleic Acids Res       Date:  2007-07-18       Impact factor: 16.971
  9 in total

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