Literature DB >> 877571

Inhibition of a lymphocyte membrane enzyme by delta9-tetrahydrocannabinol in vitro.

J H Greenberg, M E Saunders, A Mellors.   

Abstract

Delta-9-tetrahydrocannabinol (delta9-THC) inhibited the activity of lysolecithin acyl transferase, a membrane-bound lymphocyte enzyme, at concentrations above 1.3 muM. Stimulation of acyl transferase activity by concanavalin A, an early response in lymphocyte activation, was entirely abolished in the presence of delta9-THC.

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Year:  1977        PMID: 877571     DOI: 10.1126/science.877571

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  2 in total

1.  Enzymic regulation of arachidonate metabolism in brain membrane phosphoglycerides.

Authors:  G Y Sun; K L Su; O M Der; W Tang
Journal:  Lipids       Date:  1979-02       Impact factor: 1.880

Review 2.  Toward drugs derived from cannabis.

Authors:  R Mechoulam; E A Carlini
Journal:  Naturwissenschaften       Date:  1978-04
  2 in total

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