Literature DB >> 877546

Clomid or nafoxidine administered to neonatal rats causes reproductive tract abnormalities.

J H Clark, S McCormack.   

Abstract

A single injection of either Clomid or Nafoxidine in neonatal rats causes multiple abnormalities of the reproductive tract of the adult female animal. These anomalies include cystic ovaries, ovarian hypoplasia, hilus cell tumors, oviductal hyperplasia, pyometra, epithelial metaplasia, uterine cystic hyperplasia, and tumors of the uterus.

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Year:  1977        PMID： 877546     DOI： 10.1126/science.877546

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  5 in total

Review 1.  The special case of hormonal imprinting, the neonatal influence of sex.

Authors:  K D Döhler
Journal:  Experientia       Date:  1986-07-15

2.  Role of estrogen receptor binding and transcriptional activity in the stimulation of hyperestrogenism and nuclear bodies.

Authors:  J H Clark; J W Hardin; H A Padykula; C A Cardasis
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205

Review 3.  Potential Teratogenic Effects of Clomiphene Citrate.

Authors:  Alessandra Scaparrotta; Francesco Chiarelli; Alberto Verrotti
Journal:  Drug Saf       Date:  2017-09       Impact factor: 5.606

Review 4.  Adverse effects of fertility drugs.

Authors:  S G Derman; E Y Adashi
Journal:  Drug Saf       Date:  1994-12       Impact factor: 5.606

5.  The relationship of the oestrogen and progestin receptors in the abnormal uterus of the adult anovulatory rat. Effects of neonatal treatment with testosterone propionate or clomiphene citrate.

Authors:  J O White; P A Moore; M G Elder; L Lim
Journal:  Biochem J       Date:  1981-05-15       Impact factor: 3.857
  5 in total

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