OBJECTIVE: To study regional blood flow of the striatum in non-ketotic hyperglycaemic choreic patients. METHODS: Brain SPECT was performed with intravenous injection of 20 mCi 99mTc hexamethylpropylene amineoxime in six non-ketotic hyperglycaemic choreic patients and 10 age matched patients with a similar level of hyperglycaemia without chorea as a control. The focal perfusion defects were analysed by visual interpretation and semiquantitative determination with reference to homolateral occipital blood flow. RESULTS: The measured blood flow of striatum on the contralateral side of chorea was significantly decreased. CONCLUSIONS: Hypometabolism of the striatum is seen not only in Huntington's disease, but also in non-ketotic hyperglycaemic chorea. Hypofunction of the striatum is a possible common pathogenesis in the development of contralateral chorea in different diseases. Furthermore, the sensitivity and reliability of SPECT is as good as PET in assessing choreic patients.
OBJECTIVE: To study regional blood flow of the striatum in non-ketotic hyperglycaemic choreicpatients. METHODS: Brain SPECT was performed with intravenous injection of 20 mCi 99mTc hexamethylpropylene amineoxime in six non-ketotic hyperglycaemic choreicpatients and 10 age matched patients with a similar level of hyperglycaemia without chorea as a control. The focal perfusion defects were analysed by visual interpretation and semiquantitative determination with reference to homolateral occipital blood flow. RESULTS: The measured blood flow of striatum on the contralateral side of chorea was significantly decreased. CONCLUSIONS: Hypometabolism of the striatum is seen not only in Huntington's disease, but also in non-ketotic hyperglycaemic chorea. Hypofunction of the striatum is a possible common pathogenesis in the development of contralateral chorea in different diseases. Furthermore, the sensitivity and reliability of SPECT is as good as PET in assessing choreicpatients.
Authors: S R Hammond; D R English; C de Wytt; J F Hallpike; K S Millingen; E G Stewart-Wynne; J G McLeod; M G McCall Journal: J Neurol Neurosurg Psychiatry Date: 1989-01 Impact factor: 10.154
Authors: S Hosokawa; Y Ichiya; Y Kuwabara; Z Ayabe; K Mitsuo; I Goto; M Kato Journal: J Neurol Neurosurg Psychiatry Date: 1987-10 Impact factor: 10.154
Authors: M Otsuka; Y Ichiya; Y Kuwabara; S Hosokawa; M Sasaki; T Fukumura; K Masuda; I Goto; M Kato Journal: J Neurol Sci Date: 1993-04 Impact factor: 3.181