PURPOSE: The purpose of this randomized controlled double blind study was to compare the efficacy of pain relief and the side effects of epidural hydromorphone and morphine in post-Caesarean patients. METHODS: In all patients, epidural anaesthesia was induced using carbonated lidocaine 2% with 1:200,000 epinephrine and 50 micrograms fentanyl, given in incremental doses. Patients in Group 1 (n = 24) received 0.6 mg hydromorphone and patients in Group 2 (n = 22) received 3 mg morphine after delivery of the infant. Pain, pruritus and nausea were measured using a visual analog scale (at times: baseline, on admission to the recovery room, 3, 6, 12, 18 and 24 hr postoperatively), by the number of requests for additional medications and by an overall satisfaction score. RESULTS: There was no difference between the groups in pain relief of in the incidence and severity of side effects. Pruritus was more pronounced within the first six hours in Group 1 and at 18 hr in Group 2. CONCLUSION:Hydromorphone provides no clinical benefit over epidural morphine for post operative analgesia following Caesarean section.
RCT Entities:
PURPOSE: The purpose of this randomized controlled double blind study was to compare the efficacy of pain relief and the side effects of epidural hydromorphone and morphine in post-Caesarean patients. METHODS: In all patients, epidural anaesthesia was induced using carbonated lidocaine 2% with 1:200,000 epinephrine and 50 micrograms fentanyl, given in incremental doses. Patients in Group 1 (n = 24) received 0.6 mg hydromorphone and patients in Group 2 (n = 22) received 3 mg morphine after delivery of the infant. Pain, pruritus and nausea were measured using a visual analog scale (at times: baseline, on admission to the recovery room, 3, 6, 12, 18 and 24 hr postoperatively), by the number of requests for additional medications and by an overall satisfaction score. RESULTS: There was no difference between the groups in pain relief of in the incidence and severity of side effects. Pruritus was more pronounced within the first six hours in Group 1 and at 18 hr in Group 2. CONCLUSION:Hydromorphone provides no clinical benefit over epidural morphine for post operative analgesia following Caesarean section.
Authors: John L Plummer; Patricia L Cmielewski; Geoffrey D Reynolds; Geoffrey K Gourlay; David A Cherry Journal: Pain Date: 1990-03 Impact factor: 6.961
Authors: J D Vertommen; H Van Aken; E Vandermeulen; M Vangerven; H Devlieger; A F Van Assche; S M Shnider Journal: J Clin Anesth Date: 1991 Sep-Oct Impact factor: 9.452
Authors: Emily E Sharpe; Rochelle J Molitor; Katherine W Arendt; Vanessa E Torbenson; David A Olsen; Rebecca L Johnson; Darrell R Schroeder; Adam K Jacob; Adam D Niesen; Hans P Sviggum Journal: Anesthesiology Date: 2020-06 Impact factor: 7.892