| Literature DB >> 8773602 |
Y Xia1, H A Rohan de Silva, B L Rosi, L H Yamaoka, J B Rimmler, M A Pericak-Vance, A D Roses, X Chen, E Masliah, R DeTeresa, A Iwai, M Sundsmo, R G Thomas, C R Hofstetter, E Gregory, L A Hansen, R Katzman, L J Thal, T Saitoh.
Abstract
The non-Abeta component of Alzheimer's disease amyloid (NAC) is copurified with amyloid from the brain tissue of Alzheimer's disease victims and is immunohistochemically localized to amyloid fibrils. NAC is a hydrophobic peptide fragment from the NAC precursor protein (NACP/alpha-synuclein) that is localized to presynaptic terminals. We used a polymorphic dinucleotide repeat sequence in a genomic clone of NACP for genetic association and linkage studies. Screening of Alzheimer's disease families failed to establish linkage between NACP and Alzheimer's disease. Nevertheless, one of the NACP polymorphisms (NACP allele 2) was shown to have significant association with healthy elderly control individuals with apolipoprotein E risk. This may indicate a possible protective function of the allele.Entities:
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Year: 1996 PMID： 8773602 DOI： 10.1002/ana.410400212
Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422