Literature DB >> 8770642

Generation of a murine monoclonal antibody specific for N-glycolylneuraminic acid-containing gangliosides that also recognizes sulfated glycolipids.

A M Vázquez1, M Alfonso, B Lanne, K A Karlsson, A Carr, O Barroso, L E Fernández, E Rengifo, M E Lanio, C Alvarez.   

Abstract

The P3 murine monoclonal antibody (MAb) was generated by immunizing BALB/c mice with NeuGcGM3 included into liposomes. The specificity of this MAb was defined by an enzyme-linked immunosorbent assay and immunostaining on thin-layer chromatograms. P3 MAb binds to NeuGc-containing gangliosides and was shown also to react with sulfated glycolipids. A preliminary immunohistochemical study showed that the P3 MAb was able to recognize antigens expressed in human breast tumors.

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Year:  1995        PMID： 8770642     DOI： 10.1089/hyb.1995.14.551

Source DB:  PubMed          Journal:  Hybridoma        ISSN： 0272-457X


  24 in total

1.  Immunopotentiating properties of a multispecific α-anti-idiotype antibody.

Authors:  Tays Hernández; Cristina Mateo de Acosta; Rolando Pérez
Journal:  MAbs       Date:  2012-04-26       Impact factor: 5.857

2.  Innate-immunity cytokines induced by very small size proteoliposomes, a Neisseria-derived immunological adjuvant.

Authors:  C Venier; M D Guthmann; L E Fernández; L Fainboim
Journal:  Clin Exp Immunol       Date:  2007-02       Impact factor: 4.330

3.  A shift from N-glycolyl- to N-acetyl-sialic acid in the GM3 ganglioside impairs tumor development in mouse lymphocytic leukemia cells.

Authors:  Ana Victoria Casadesús; Yuniel Fernández-Marrero; Marilyn Clavell; José Alberto Gómez; Tays Hernández; Ernesto Moreno; Alejandro López-Requena
Journal:  Glycoconj J       Date:  2013-04-02       Impact factor: 2.916

Review 4.  Lonely killers: effector cell- and complement-independent non-proapoptotic cytotoxic antibodies inducing membrane lesions.

Authors:  Yuniel Fernández-Marrero; Alejandro López-Requena
Journal:  MAbs       Date:  2011-11-01       Impact factor: 5.857

5.  Bovine milk gangliosides: changes in ceramide moiety with stage of lactation.

Authors:  M J Martín; S Martín-Sosa; P Hueso
Journal:  Lipids       Date:  2001-03       Impact factor: 1.880

6.  Lactational changes in the fatty acid composition of human milk gangliosides.

Authors:  Samuel Martín-Sosa; María-Jesús Martín; María-Dolores Castro; José A Cabezas; Pablo Hueso
Journal:  Lipids       Date:  2004-02       Impact factor: 1.880

7.  Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid.

Authors:  Pam Tangvoranuntakul; Pascal Gagneux; Sandra Diaz; Muriel Bardor; Nissi Varki; Ajit Varki; Elaine Muchmore
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-01       Impact factor: 11.205

8.  Anti-idiotype antibodies in cancer treatment: the pharmaceutical industry perspective.

Authors:  Roberto E Gómez; Maria L Ardigo
Journal:  Front Oncol       Date:  2012-10-29       Impact factor: 6.244

9.  Racotumomab: an anti-idiotype vaccine related to N-glycolyl-containing gangliosides - preclinical and clinical data.

Authors:  Ana M Vázquez; Ana M Hernández; Amparo Macías; Enrique Montero; Daniel E Gómez; Daniel F Alonso; Mariano R Gabri; Roberto E Gómez
Journal:  Front Oncol       Date:  2012-10-23       Impact factor: 6.244

10.  Anti-ganglioside anti-idiotypic vaccination: more than molecular mimicry.

Authors:  Ana M H Vázquez; Nely Rodrèguez-Zhurbenko; Ana M V López
Journal:  Front Oncol       Date:  2012-11-20       Impact factor: 6.244
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