[Zinc--update of an essential trace element].

Since the recognition of zinc as an essential trace element in man and animals there has been a remarkable progress in our knowledge of the role of zinc in nutritional physiology, biology and medicine during the last few decades. Highlights in zinc research, mechanisms and homeostatic regulation of zinc absorption, sources of zinc intake, dietary factors and mineral interactions affecting zinc bioavailability are reviewed in the present paper. This is followed by an overview of the biochemical functions of zinc in enzymes, gene expression, endocrinology, immunology and oxidative stress. General signs and metabolic consequences of zinc deficiency as well as excessive intake and toxicity of zinc are summarized. Furthermore, national and international dietary zinc recommendations and different methods to determine the zinc status are discussed.