Literature DB >> 8766819

Role of ascorbic acid in the metabolism of S-nitroso-glutathione.

M Kashiba-Iwatsuki1, M Yamaguchi, M Inoue.   

Abstract

Although nitric oxide (NO) has been known to generate S-nitroso-thiols (RSNOs), dynamic aspects of their metabolism remain to be elucidated. The present work reports the reactivity of S-nitroso-glutathione (GS-NO) with various compounds with reducing activity. Kinetic analysis revealed that among various reagents tested, ascorbic acid showed a potent activity to decompose GS-NO to glutathione and oxidized products of NO. During the reaction of GS-NO and ascorbic acid, monodehydroascorbate was found to appear as an intermediate. These results suggest that ascorbic acid might be an important modulator for RS-NO metabolism.

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Year:  1996        PMID： 8766819     DOI： 10.1016/0014-5793(96)00560-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

Review 1.  Nitric oxide metabolism in asthma pathophysiology.

Authors:  Sudakshina Ghosh; Serpil C Erzurum
Journal:  Biochim Biophys Acta       Date:  2011-06-21

2.  Role of quinones in the ascorbate reduction rates of S-nitrosoglutathione.

Authors:  Pedro Sanchez-Cruz; Carmelo Garcia; Antonio E Alegria
Journal:  Free Radic Biol Med       Date:  2010-08-05       Impact factor: 7.376

3.  Copper dependence of the biotin switch assay: modified assay for measuring cellular and blood nitrosated proteins.

Authors:  Xunde Wang; Nicholas J Kettenhofen; Sruti Shiva; Neil Hogg; Mark T Gladwin
Journal:  Free Radic Biol Med       Date:  2008-01-04       Impact factor: 7.376

4.  Quinone-enhanced sonochemical production of nitric oxide from s-nitrosoglutathione.

Authors:  Antonio E Alegría; Francisco J Dejesús-Andino; Pedro Sanchez-Cruz
Journal:  Ultrason Sonochem       Date:  2008-05-24       Impact factor: 7.491

5.  Effect of Some nitrosative agents on the growth of vgb-bearing Enterobacter aerogenes strains.

Authors:  Khaled M Khleifat; Ahmed H Al-Mustafa
Journal:  Curr Microbiol       Date:  2007-05-28       Impact factor: 2.188

Review 6.  In-gel detection of S-nitrosated proteins using fluorescence methods.

Authors:  Nicholas J Kettenhofen; Xunde Wang; Mark T Gladwin; Neil Hogg
Journal:  Methods Enzymol       Date:  2008       Impact factor: 1.600

7.  Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation.

Authors:  Edward T Chouchani; Thomas R Hurd; Sergiy M Nadtochiy; Paul S Brookes; Ian M Fearnley; Kathryn S Lilley; Robin A J Smith; Michael P Murphy
Journal:  Biochem J       Date:  2010-08-15       Impact factor: 3.857

Review 8.  Hydropersulfides (RSSH) and Nitric Oxide (NO) Signaling: Possible Effects on S-Nitrosothiols (RS-NO).

Authors:  Jon M Fukuto; Cristina Perez-Ternero; Jessica Zarenkiewicz; Joseph Lin; Adrian J Hobbs; John P Toscano
Journal:  Antioxidants (Basel)       Date:  2022-01-16
  8 in total

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