BACKGROUND: Vein thromboses are not seldom, even in young patients. The pathogenesis of such perfusion disorders is poorly understood-accordingly, it is difficult to choose therapy specific to the causality and appropriate prophylaxis against recurrence. PATIENTS AND METHODS: In a retrospective study we analyzed the clinical findings of seven patients under 45 years of age who suffered a retinal vein occlusion in the past two years. RESULTS: Anatomical changes of the vessels in carotis and ophthalmica regions were not found, as was the case in hemostasis and fibrinolysis, as well. However, all patients reported stress problems in family and occupation. Migraine was often mentioned in the anamnesis. Coldness of the extremities and perfusion disorders in the nailfold capillaries examined under capillary microscopy indicated increased vasospasm. CONCLUSIONS: Vein thromboses are affections of both the arterial and venous circulation. We hypothesize that dysregulation of vascular tone plays an essential role in the genesis of retinal vein thromboses. Increased vasospasm and the incapacity to reactively dilate are potential mechanisms for such perfusion disorders. When counseling patients and applying medical therapy, such a possible pathogenesis should be taken into consideration.
BACKGROUND: Vein thromboses are not seldom, even in young patients. The pathogenesis of such perfusion disorders is poorly understood-accordingly, it is difficult to choose therapy specific to the causality and appropriate prophylaxis against recurrence. PATIENTS AND METHODS: In a retrospective study we analyzed the clinical findings of seven patients under 45 years of age who suffered a retinal vein occlusion in the past two years. RESULTS: Anatomical changes of the vessels in carotis and ophthalmica regions were not found, as was the case in hemostasis and fibrinolysis, as well. However, all patients reported stress problems in family and occupation. Migraine was often mentioned in the anamnesis. Coldness of the extremities and perfusion disorders in the nailfold capillaries examined under capillary microscopy indicated increased vasospasm. CONCLUSIONS: Vein thromboses are affections of both the arterial and venous circulation. We hypothesize that dysregulation of vascular tone plays an essential role in the genesis of retinal vein thromboses. Increased vasospasm and the incapacity to reactively dilate are potential mechanisms for such perfusion disorders. When counseling patients and applying medical therapy, such a possible pathogenesis should be taken into consideration.
Authors: Maneli Mozaffarieh; Daniela Hauenstein; Andreas Schoetzau; Katarzyna Konieczka; Josef Flammer Journal: Mol Vis Date: 2010-03-23 Impact factor: 2.367
Authors: Josef Flammer; Katarzyna Konieczka; Rosa M Bruno; Agostino Virdis; Andreas J Flammer; Stefano Taddei Journal: Eur Heart J Date: 2013-02-10 Impact factor: 29.983