| Literature DB >> 8764998 |
H W van den Hooven1, F M Lagerwerf, W Heerma, J Haverkamp, J C Piard, C W Hilbers, R J Siezen, O P Kuipers, H S Rollema.
Abstract
The lantibiotic lacticin 481 is a bacteriocin produced by Lactococcus lactis ssp. lactis. This polypeptide contains 27 amino acids, including the unusual residues dehydrobutyrine and the thioether-bridging lanthionine and 3-methyllanthionine. Lacticin 481 belongs to a structurally distinct group of lantibiotics, which also include streptococcin A-FF22, salivaricin A and variacin. Here we report the first complete structure of this type of lantibiotic. The exact location of the thioether bridges in lacticin 481 was determined by a combination of peptide chemistry, mass spectrometry and NMR spectroscopy, showing connections between residues 9 and 14, 11 and 25, and 18 and 26.Entities:
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Year: 1996 PMID： 8764998 DOI： 10.1016/0014-5793(96)00771-5
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124