Literature DB >> 8764470

Cellular transformation by human T-cell leukemia virus type I.

S Ressler1, L M Connor, S J Marriott.   

Abstract

Human T-cell leukemia virus type I (HTLV-I) is an oncogenic retrovirus that was isolated in 1980 from a patient with adult T-cell leukemia. From the numerous experiments using infected patient T-cells, transgenic mice and tissue culture transformation assays, the Tax protein has been determined to be the transforming component of HTLV-I. Tax-mediated transformation is linked to its ability to transcriptionally regulate the expression of cellular genes involved in growth and proliferation. Ultimately, unregulated and continued activation of these important growth modulating genes by Tax leads to transformation.

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Year:  1996        PMID： 8764470     DOI： 10.1111/j.1574-6968.1996.tb08322.x

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  10 in total

1.  Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha.

Authors:  G Xiao; M E Cvijic; A Fong; E W Harhaj; M T Uhlik; M Waterfield; S C Sun
Journal:  EMBO J       Date:  2001-12-03       Impact factor: 11.598

2.  Discordance between bovine leukemia virus tax immortalization in vitro and oncogenicity in vivo.

Authors:  J C Twizere; P Kerkhofs; A Burny; D Portetelle; R Kettmann; L Willems
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

Review 3.  Molecular mechanism of immune response, synovial proliferation and apoptosis in rheumatoid arthritis.

Authors:  T Hasunuma; T Kato; T Kobata; K Nishioka
Journal:  Springer Semin Immunopathol       Date:  1998

4.  Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation.

Authors:  C A Pise-Masison; R Mahieux; H Jiang; M Ashcroft; M Radonovich; J Duvall; C Guillerm; J N Brady
Journal:  Mol Cell Biol       Date:  2000-05       Impact factor: 4.272

5.  Association of SRC-related kinase Lyn with the interleukin-2 receptor and its role in maintaining constitutive phosphorylation of JAK/STAT in human T-cell leukemia virus type 1-transformed T cells.

Authors:  Maureen Shuh; Barry A Morse; Gisela Heidecker; David Derse
Journal:  J Virol       Date:  2011-02-23       Impact factor: 5.103

Review 6.  Regulation of NF-kappaB by the HTLV-1 Tax protein.

Authors:  X H Li; R B Gaynor
Journal:  Gene Expr       Date:  1999

7.  Bovine leukemia virus structural gene vectors are immunogenic and lack pathogenicity in a rabbit model.

Authors:  L Kucerova; V Altanerova; C Altaner; K Boris-Lawrie
Journal:  J Virol       Date:  1999-10       Impact factor: 5.103

8.  B-lymphocyte proliferation during bovine leukemia virus-induced persistent lymphocytosis is enhanced by T-lymphocyte-derived interleukin-2.

Authors:  E S Trueblood; W C Brown; G H Palmer; W C Davis; D M Stone; T F McElwain
Journal:  J Virol       Date:  1998-04       Impact factor: 5.103

9.  Human T Lymphotropic Virus Type 1 (HTLV-1): Molecular Biology and Oncogenesis.

Authors:  Priya Kannian; Patrick L Green
Journal:  Viruses       Date:  2010-09-24       Impact factor: 5.818

Review 10.  Targeting K-Ras and apoptosis-driven cellular transformation in cancer.

Authors:  Isha Godwin; Nikhil Ponnoor Anto; Smitha V Bava; Mani Shankar Babu; Goodwin G Jinesh
Journal:  Cell Death Discov       Date:  2021-04-14
  10 in total

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