Literature DB >> 8764099

Grb10: A new substrate of the insulin-like growth factor I receptor.

A Morrione1, B Valentinis, S Li, J Y Ooi, B Margolis, R Baserga.   

Abstract

Using the yeast two-hybrid system, we have isolated a new substrate of the insulin-like growth factor I receptor (IGF-IR), identified as Grb10, a member of the family of SH2 domain proteins. With the help of several mutants of the IGF-IR, we have mapped the binding site of Grb10 between amino acids 1229 and 1245 of the receptor, a sequence that is dispensable for the mitogenic activity of the IGF-IR. Grb10 coprecipitates with the IGF-IR in cell lysates and is probably involved in the regulation of its activity.

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Year:  1996        PMID： 8764099

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  19 in total

Review 1.  Tissue-specific regulation and function of Grb10 during growth and neuronal commitment.

Authors:  Robert N Plasschaert; Marisa S Bartolomei
Journal:  Proc Natl Acad Sci U S A       Date:  2014-11-03       Impact factor: 11.205

2.  Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis.

Authors:  J Wang; H Dai; N Yousaf; M Moussaif; Y Deng; A Boufelliga; O R Swamy; M E Leone; H Riedel
Journal:  Mol Cell Biol       Date:  1999-09       Impact factor: 4.272

Review 3.  Grb10 is a dual regulator of receptor tyrosine kinase signaling.

Authors:  Nuzhat N Kabir; Julhash U Kazi
Journal:  Mol Biol Rep       Date:  2014-01-14       Impact factor: 2.316

4.  RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix.

Authors:  Ulrich Hermanto; Cong S Zong; Weiqun Li; Lu-Hai Wang
Journal:  Mol Cell Biol       Date:  2002-04       Impact factor: 4.272

Review 5.  Binding of SH2 containing proteins to the insulin receptor: a new way for modulating insulin signalling.

Authors:  F Liu; R A Roth
Journal:  Mol Cell Biochem       Date:  1998-05       Impact factor: 3.396

Review 6.  The origin and evolution of genomic imprinting and viviparity in mammals.

Authors:  Marilyn B Renfree; Shunsuke Suzuki; Tomoko Kaneko-Ishino
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2013-01-05       Impact factor: 6.237

Review 7.  Grb10 and Grb14: enigmatic regulators of insulin action--and more?

Authors:  Lowenna J Holt; Kenneth Siddle
Journal:  Biochem J       Date:  2005-06-01       Impact factor: 3.857

8.  FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia.

Authors:  Julhash U Kazi; Lars Rönnstrand
Journal:  Mol Oncol       Date:  2012-11-29       Impact factor: 6.603

9.  Imprinted methylation profiles for proximal mouse chromosomes 11 and 7 as revealed by methylation-sensitive representational difference analysis.

Authors:  David Monk; Rachel Smith; Philippe Arnaud; Michael A Preece; Philip Stanier; Colin V Beechey; Jo Peters; Gavin Kelsey; Gudrun E Moore
Journal:  Mamm Genome       Date:  2003-12       Impact factor: 2.957

10.  The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor.

Authors:  Andrea Vecchione; Adriano Marchese; Pauline Henry; Daniela Rotin; Andrea Morrione
Journal:  Mol Cell Biol       Date:  2003-05       Impact factor: 4.272
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