Literature DB >> 8764077

cis-acting elements that mediate the negative regulation of Moloney murine leukemia virus in mouse early embryos.

M Vernet1, J Cebrian.   

Abstract

We have addressed the question of the nature of Moloney murine leukemia virus (MoMuLV) repression in mouse embryos by assaying for the transient expression of MoMuLV-derived constructs microinjected into early cleavage embryos. We show that the same cis-acting DNA sequences responsible for the block in MoMuLV expression in embryonal carcinoma cell lines operate in early embryos: (i) the MoMuLV long terminal repeat is nonfunctional, and (ii) the +147 to +163 repressor binding site, or negative regulatory element, negatively regulates the expression from an active promoter.

Entities:  

Mesh：

Year:  1996        PMID： 8764077      PMCID： PMC190523     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  30 in total

1.  A beta-galactosidase hybrid protein targeted to nuclei as a marker for developmental studies.

Authors:  C Bonnerot; D Rocancourt; P Briand; G Grimber; J F Nicolas
Journal:  Proc Natl Acad Sci U S A       Date:  1987-10       Impact factor: 11.205

2.  An embryonic DNA-binding protein specific for the promoter of the retrovirus long terminal repeat.

Authors:  F Flamant; C C Gurin; J A Sorge
Journal:  Mol Cell Biol       Date:  1987-10       Impact factor: 4.272

3.  Negative regulation of retrovirus expression in embryonal carcinoma cells mediated by an intragenic domain.

Authors:  T P Loh; L L Sievert; R W Scott
Journal:  J Virol       Date:  1988-11       Impact factor: 5.103

4.  Two distinct sequence elements mediate retroviral gene expression in embryonal carcinoma cells.

Authors:  H Weiher; E Barklis; W Ostertag; R Jaenisch
Journal:  J Virol       Date:  1987-09       Impact factor: 5.103

5.  Mechanism of suppression of the long terminal repeat of Moloney leukemia virus in mouse embryonal carcinoma cells.

Authors:  T Tsukiyama; O Niwa; K Yokoro
Journal:  Mol Cell Biol       Date:  1989-11       Impact factor: 4.272

6.  Two blocks in Moloney murine leukemia virus expression in undifferentiated F9 embryonal carcinoma cells as determined by transient expression assays.

Authors:  G Feuer; M Taketo; R C Hanecak; H Fan
Journal:  J Virol       Date:  1989-05       Impact factor: 5.103

7.  Proviral sequences that restrict retroviral expression in mouse embryonal carcinoma cells.

Authors:  T P Loh; L L Sievert; R W Scott
Journal:  Mol Cell Biol       Date:  1987-10       Impact factor: 4.272

8.  Infection of preimplantation mouse embryos and of newborn mice with leukemia virus: tissue distribution of viral DNA and RNA and leukemogenesis in the adult animal.

Authors:  R Jaenisch; H Fan; B Croker
Journal:  Proc Natl Acad Sci U S A       Date:  1975-10       Impact factor: 11.205

9.  Evidence for a stem cell-specific repressor of Moloney murine leukemia virus expression in embryonal carcinoma cells.

Authors:  T P Loh; L L Sievert; R W Scott
Journal:  Mol Cell Biol       Date:  1990-08       Impact factor: 4.272

10.  Permissiveness to murine leukemia, virus expression during preimplantation and early postimplantation mouse development.

Authors:  P Savatier; J Morgenstern; R S Beddington
Journal:  Development       Date:  1990-07       Impact factor: 6.868
View more
  3 in total

1.  Lack of shielding of primer binding site silencer-mediated repression of an internal promoter in a retrovirus vector by the putative insulators scs, BEAD-1, and HS4.

Authors:  C Modin; F S Pedersen; M Duch
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

2.  Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET.

Authors:  Toshiyuki Matsui; Danny Leung; Hiroki Miyashita; Irina A Maksakova; Hitoshi Miyachi; Hiroshi Kimura; Makoto Tachibana; Matthew C Lorincz; Yoichi Shinkai
Journal:  Nature       Date:  2010-02-17       Impact factor: 49.962

Review 3.  Viral vectors for gene transfer: a review of their use in the treatment of human diseases.

Authors:  W Walther; U Stein
Journal:  Drugs       Date:  2000-08       Impact factor: 11.431
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.