Genetic architecture of EEG power spectra in early life.

We measured the electroencephalogram (EEG) in 209 5 year old monozygotic (MZ) and dizygotic (DZ) twin pairs to estimate the relative contribution of genetic and environmental factors to EEG power spectra in early life. Data from same-sex and from opposite-sex twin pairs were used to test for sex differences in genetic influences. Results showed high concordance for EEGs of MZ twins for absolute and relative power in delta, theta, alpha 1, alpha 2, beta 1 and beta 2 bands. A model with additive genetic and unique environmental influences explained individual differences in both absolute and relative power in almost all bands and all electrode positions. Heritability of EEG power spectra was high. For absolute power the highest heritabilities were observed in theta, alpha 1, alpha 2 and beta 1 power bands (mean heritability 81, 81, 78, and 73%, respectively). Somewhat lower heritabilities were found in delta and beta 2 bands (mean heritability 55 and 64%, respectively). For relative power heritabilities were 63, 76, 71, 72, 68, and 65 for delta, theta, alpha 1, alpha 2, beta 1, and beta 2, respectively. Virtually no sex differences in heritability were found. These findings indicate that the background EEG is one of the most heritable characteristics in early life.