Antigens with application toward immune control of blood-feeding parasitic nematodes.

This review considers progress toward immune control of nematode parasites that feed on mammalian host blood. Approaches to identify relevant parasite antigens include use of irradiated larvae, somatic antigens, metabolites, enzymes and gut antigens. Because significant immune protection has more recently been achieved using gut antigens of the blood-feeding parasite Haemonchus contortus, these antigens are considered in greater detail. Issues discussed are implications of gut antigens in immune control, potential mechanisms involved in this immunity, biochemical characteristics of gut antigens and potential application of gut antigens to immune control of other blood-feeding nematodes.