| Literature DB >> 8761377 |
O Nativ1, O Medalia, Y Mor, I Shajrawi, E Sabo, M Aronson.
Abstract
The purpose of the present study was to explore the therapeutic potential of serial administration of shedding-inducing endotoxin in a mouse tumour bladder model. The studies were conducted with two variants derived from the MBT-2 tumour namely, T5 and T50, the latter being far more aggressive than the former. It was found that T5 tumours responded to intravesical lipopolysaccharides (LPS) instillation by a considerable reduction in their pace of growth (P < 0.0001) when treatment was initiated 3 days after tumour implantation, but not when started after 7 days. The T50 variant did not respond to LPS when treated 3 days after implantation, but a considerable reduction in rate of growth occurred when treatment was started after 1-2 days. Shedding induced by intravesically instilled LPS was found to retard considerably the progression rate of experimental bladder tumour.Entities:
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Year: 1996 PMID： 8761377 PMCID： PMC2074659 DOI： 10.1038/bjc.1996.408
Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640