Literature DB >> 8761002

PACAP stimulates c-fos mRNAs in small cell lung cancer cells.

M Draoui1, T Hida, S Jakowlew, M Birrer, F Zia, T W Moody.   

Abstract

The effects of PACAP on c-fos mRNA using small cell lung cancer (SCLC) cell was investigated. PACAP-27 (100 nM) increased c-fos mRNA 5-fold using NCI-N417 cells. The increase was concentration dependent with 0.1 nM PACAP-27 half maximally increasing c-fos mRNA. Also the increase in c-fos mRNA caused by PACAP was time dependent; being maximal after 1 hour and returning to basal values after 4 hours. PACAP-38 but not PACAP(28-38) increased c-fos mRNA. One uM PACAP(6-38), a PACAP receptor antagonist, inhibited the increase in c-fos mRNA caused by 1 nM PACAP. These data indicate that PACAP stimulates nuclear oncogene expression in SCLC cells.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8761002     DOI： 10.1016/0024-3205(96)00299-8

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  7 in total

1.  PACAP immunoreactivity in human malignant tumor samples and cardiac diseases.

Authors:  Z Szanto; Zs Sarszegi; D Reglodi; J Nemeth; K Szabadfi; P Kiss; A Varga; E Banki; K Csanaky; B Gaszner; O Pinter; Zs Szalai; A Tamas
Journal:  J Mol Neurosci       Date:  2012-05-31       Impact factor: 3.444

2.  Pituitary adenylate cyclase-activating polypeptide causes tyrosine phosphorylation of the epidermal growth factor receptor in lung cancer cells.

Authors:  Terry W Moody; Nauramy Osefo; Bernardo Nuche-Berenguer; Lisa Ridnour; David Wink; Robert T Jensen
Journal:  J Pharmacol Exp Ther       Date:  2012-03-02       Impact factor: 4.030

3.  Pituitary adenylate cyclase-activating polypeptide causes increased tyrosine phosphorylation of focal adhesion kinase and paxillin.

Authors:  Terry W Moody; Julius Leyton; Robert T Jensen
Journal:  J Mol Neurosci       Date:  2011-09-06       Impact factor: 3.444

4.  PAC1 regulates receptor tyrosine kinase transactivation in a reactive oxygen species-dependent manner.

Authors:  Terry W Moody; Lingaku Lee; Tatiana Iordanskaia; Irene Ramos-Alvarez; Paola Moreno; Howard E Boudreau; Thomas L Leto; Robert T Jensen
Journal:  Peptides       Date:  2018-09-28       Impact factor: 3.750

5.  PACAP-27 tyrosine phosphorylates mitogen activated protein kinase and increases VEGF mRNAs in human lung cancer cells.

Authors:  Terry W Moody; Julius Leyton; Marchessini Casibang; Joseph Pisegna; Robert T Jensen
Journal:  Regul Pept       Date:  2002-11-15

6.  The G Protein-Coupled Receptor PAC1 Regulates Transactivation of the Receptor Tyrosine Kinase HER3.

Authors:  Terry W Moody; Lingaku Lee; Robert T Jensen
Journal:  J Mol Neurosci       Date:  2020-09-22       Impact factor: 2.866

Review 7.  Protective Effects of PACAP in Peripheral Organs.

Authors:  Denes Toth; Edina Szabo; Andrea Tamas; Tamas Juhasz; Gabriella Horvath; Eszter Fabian; Balazs Opper; Dora Szabo; Grazia Maugeri; Agata G D'Amico; Velia D'Agata; Viktoria Vicena; Dora Reglodi
Journal:  Front Endocrinol (Lausanne)       Date:  2020-07-14       Impact factor: 5.555
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.