Literature DB >> 8760414

Cell death induced by cytopathic bovine viral diarrhoea virus is mediated by apoptosis.

G Zhang1, S Aldridge, M C Clarke, J W McCauley.   

Abstract

Cells infected with two closely related isolates of bovine viral diarrhoea virus (BVDV), one cytopathic (CP) and one non-cytopathic (NCP), were examined for signs of apoptosis. The results from labelling DNA using terminal transferase and biotinylated dUTP and by observing oligonucleosomal-sized DNA fragmentation indicated that the CP strain of BVDV induced apoptosis in cell culture but the NCP strain did not. Induction of apoptosis correlated with infected cells undergoing apoptosis rather than interactions between infected and uninfected cells and the induction of apoptosis by CP BVDV was a dominant trait in cells co-infected with both types of virus.

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Year:  1996        PMID： 8760414     DOI： 10.1099/0022-1317-77-8-1677

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  26 in total

1.  The effects of cytopathic and noncytopathic bovine viral diarrhoea virus with sperm cells on in vitro fertilization of bovine oocytes.

Authors:  M Talebkhan Garoussi
Journal:  Vet Res Commun       Date:  2006-12-23       Impact factor: 2.459

2.  The amino-terminal domain of bovine viral diarrhea virus Npro protein is necessary for alpha/beta interferon antagonism.

Authors:  Laura H V G Gil; Israrul H Ansari; Ventzislav Vassilev; Delin Liang; Vicky C H Lai; Weidong Zhong; Zhi Hong; Edward J Dubovi; Ruben O Donis
Journal:  J Virol       Date:  2006-01       Impact factor: 5.103

3.  Glycoprotein Erns of pestiviruses induces apoptosis in lymphocytes of several species.

Authors:  C J Bruschke; M M Hulst; R J Moormann; P A van Rijn; J T van Oirschot
Journal:  J Virol       Date:  1997-09       Impact factor: 5.103

4.  In vitro and in vivo detection of Mx gene products in bovine cells following stimulation with alpha/beta interferon and viruses.

Authors:  Doris Müller-Doblies; Mathias Ackermann; Alfred Metzler
Journal:  Clin Diagn Lab Immunol       Date:  2002-11

5.  Noncytopathic bovine viral diarrhea virus inhibits double-stranded RNA-induced apoptosis and interferon synthesis.

Authors:  M Schweizer; E Peterhans
Journal:  J Virol       Date:  2001-05       Impact factor: 5.103

6.  "Self" and "nonself" manipulation of interferon defense during persistent infection: bovine viral diarrhea virus resists alpha/beta interferon without blocking antiviral activity against unrelated viruses replicating in its host cells.

Authors:  Matthias Schweizer; Philippe Mätzener; Gabriela Pfaffen; Hanspeter Stalder; Ernst Peterhans
Journal:  J Virol       Date:  2006-07       Impact factor: 5.103

7.  Infectious bovine viral diarrhea virus (strain NADL) RNA from stable cDNA clones: a cellular insert determines NS3 production and viral cytopathogenicity.

Authors:  E Mendez; N Ruggli; M S Collett; C M Rice
Journal:  J Virol       Date:  1998-06       Impact factor: 5.103

8.  Isolation and characterization of noncytopathic pestivirus mutants reveals a role for nonstructural protein NS4B in viral cytopathogenicity.

Authors:  L Qu; L K McMullan; C M Rice
Journal:  J Virol       Date:  2001-11       Impact factor: 5.103

9.  A single point mutation in nonstructural protein NS2 of bovine viral diarrhea virus results in temperature-sensitive attenuation of viral cytopathogenicity.

Authors:  Alexander Pankraz; Simone Preis; Heinz-Jürgen Thiel; Andreas Gallei; Paul Becher
Journal:  J Virol       Date:  2009-09-23       Impact factor: 5.103

10.  Replication of a cytopathic strain of bovine viral diarrhea virus activates PERK and induces endoplasmic reticulum stress-mediated apoptosis of MDBK cells.

Authors:  Robert Jordan; Lijuan Wang; Thomas M Graczyk; Timothy M Block; Patrick R Romano
Journal:  J Virol       Date:  2002-10       Impact factor: 5.103
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