| Literature DB >> 8760375 |
V Giancotti1, A Bandiera, C Sindici, L Perissin, C Crane-Robinson.
Abstract
Micrococcal nuclease digestion of nuclei from mouse Lewis lung carcinoma cells releases a protein mixture into the supernatant that lacks histone H1 and contains a full complement of high-mobility-group I (HMGI) proteins (i.e. I, Y and I-C). This implies that all three HMGI proteins are localized at the nuclease-sensitive regions of active chromatin. It is also shown that if Ca2+ ions are present in the nuclear incubation buffer (with or without exogenous nuclease), all three HMGI proteins become ADP-ribosylated. We propose that this modification of HMGI family proteins is part of the general poly(ADP-ribosyl)ation that accompanies DNA damage in apoptosis and other processes.Entities:
Mesh：
Substances：
Year: 1996 PMID： 8760375 PMCID： PMC1217565 DOI： 10.1042/bj3170865
Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857