| Literature DB >> 8759892 |
J Wijdenes1, W C Vooijs, C Clément, J Post, F Morard, N Vita, P Laurent, R X Sun, B Klein, J M Dore.
Abstract
We developed a new monoclonal antibody. B-B4, which specifically identifies human plasma cells. It strongly reacts with all multiple myeloma cell lines and with malignant plasma cells of all tumour samples of the multiple myeloma patients tested. B-B4 does not react with any peripheral blood, bone marrow or tonsil cells. Cloning of the B-B4 antigen reveals that the monoclonal antibody recognizes syndecan-1. It appears that the monoclonal antibody B-B4 is a suitable marker for human plasmocyte identification among haemopoietic cells and a useful probe for the diagnosis of haematological malignancies. Furthermore, this monoclonal antibody can be used for depletions prior to CD34 grafting.Entities:
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Year: 1996 PMID： 8759892 DOI： 10.1046/j.1365-2141.1996.d01-1811.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998