Literature DB >> 8758898

C/EBP activators are required for HIV-1 replication and proviral induction in monocytic cell lines.

A J Henderson1, R I Connor, K L Calame.   

Abstract

Previous work has shown that C/EBP sites and C/EBP transcriptional activators are necessary for HIV-1 LTR activity in monocytes/macrophages. We have investigated the role that C/EBP proteins play in induction and replication of HIV-1. Ectopic expression of the dominant negative C/EBP protein LIP inhibited HIV-1 mRNA and virus production in activated U1 cells, demonstrating that C/EBP proteins are required for provirus induction. U1 lines overexpressing C/EBP activator NF-IL-6 produced more viral mRNA and virus particles following cellular activation than control lines, demonstrating that C/EBP proteins are limiting for virus transcription. HIV-1 harboring mutations within two C/EBP sites were crippled in their ability to replicate in U937 promonocytic cells, indicating that these sites are required for replication. These data identify C/EBP proteins as regulators of HIV-1 expression in monocytes/macrophages.

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Year:  1996        PMID： 8758898     DOI： 10.1016/s1074-7613(00)80313-1

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  42 in total

1.  HIV-1 LTR C/EBP binding site sequence configurations preferentially encountered in brain lead to enhanced C/EBP factor binding and increased LTR-specific activity.

Authors:  H L Ross; S Gartner; J C McArthur; J R Corboy; J J McAllister; S Millhouse; B Wigdahl
Journal:  J Neurovirol       Date:  2001-06       Impact factor: 2.643

Review 2.  Regulation of HIV-1 transcription.

Authors:  K A Roebuck; M Saifuddin
Journal:  Gene Expr       Date:  1999

3.  Functional interactions between C/EBP, Sp1, and COUP-TF regulate human immunodeficiency virus type 1 gene transcription in human brain cells.

Authors:  C Schwartz; P Catez; O Rohr; D Lecestre; D Aunis; E Schaeffer
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

4.  Interleukin-10 induces inhibitory C/EBPbeta through STAT-3 and represses HIV-1 transcription in macrophages.

Authors:  Naohiko Tanaka; Yoshihiko Hoshino; Jeffrey Gold; Satomi Hoshino; Frank Martiniuk; Takeshi Kurata; Richard Pine; David Levy; William N Rom; Michael Weiden
Journal:  Am J Respir Cell Mol Biol       Date:  2005-07-13       Impact factor: 6.914

5.  Structural and functional studies of CCAAT/enhancer binding sites within the human immunodeficiency virus type 1 subtype C LTR.

Authors:  Yujie Liu; Michael R Nonnemacher; Devin L Stauff; Luna Li; Anupam Banerjee; Bryan Irish; Evelyn Kilareski; Nirmala Rajagopalan; Joyce B Suchitra; Zafar K Khan; Udaykumar Ranga; Brian Wigdahl
Journal:  Biomed Pharmacother       Date:  2010-09-25       Impact factor: 6.529

Review 6.  CCAAT/enhancer-binding proteins and the pathogenesis of retrovirus infection.

Authors:  Yujie Liu; Michael R Nonnemacher; Brian Wigdahl
Journal:  Future Microbiol       Date:  2009-04       Impact factor: 3.165

7.  OTK18, a zinc-finger protein, regulates human immunodeficiency virus type 1 long terminal repeat through two distinct regulatory regions.

Authors:  Masahide Horiba; Lindsey B Martinez; James L Buescher; Shinji Sato; Jenae Limoges; Yunquan Jiang; Clinton Jones; Tsuneya Ikezu
Journal:  J Gen Virol       Date:  2007-01       Impact factor: 3.891

8.  Regulation of SIV mac 239 basal long terminal repeat activity and viral replication in macrophages: functional roles of two CCAAT/enhancer-binding protein beta sites in activation and interferon beta-mediated suppression.

Authors:  Shruthi Ravimohan; Lucio Gama; Sheila A Barber; Janice E Clements
Journal:  J Biol Chem       Date:  2009-11-20       Impact factor: 5.157

9.  CCAAT/enhancer binding protein (C/EBP) sites are required for HIV-1 replication in primary macrophages but not CD4(+) T cells.

Authors:  A J Henderson; K L Calame
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-05       Impact factor: 11.205

10.  Coordinated regulation of SIV replication and immune responses in the CNS.

Authors:  Kenneth W Witwer; Lucio Gama; Ming Li; Christopher M Bartizal; Suzanne E Queen; John J Varrone; Angela K Brice; David R Graham; Patrick M Tarwater; Joseph L Mankowski; M Christine Zink; Janice E Clements
Journal:  PLoS One       Date:  2009-12-17       Impact factor: 3.240
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