Literature DB >> 8758531

[Iatrogenic drug-induced diseases, requiring hospitalization, in patients over 65 years of age. 1-year retrospective study in an internal medicine department].

G Fradet1, X Legac, T Charlois, T Ponge, S Cottin.   

Abstract

Iatrogenic pathology is mainly seen in the elderly. In a one year retrospective study, we showed that drug toxicity was responsible for 87 cases requiring hospitalisation in patients aged 65 years and above (7.7% of hospital admission for patients over 65 years). The major manifestations were: 21 cases of sera electrolyte disturbance, 19 concerning gastro-intestinal tract and liver, 16 cardiological disorders, 13 neurological complications, ten involving the endocrine system, six hematological complications. The most common drugs involved were: antihypertensive agents (36%), of which 20.5% were diuretics, psychotherapeutic drugs (24.8%), anti-inflammatory drugs (17.8%). The average cost per patient was calculated to 20,602 FF per patient. Impossibility for direct return to the original dwelling place was another complication in 29% of hospitalisations related to iatrogenic disorders. The high number of drugs taken daily increases the risk of drug interactions which was responsible for iatrogenic accidents in 12.6% of the patients of this study.

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Year:  1996        PMID: 8758531     DOI: 10.1016/0248-8663(96)86437-x

Source DB:  PubMed          Journal:  Rev Med Interne        ISSN: 0248-8663            Impact factor:   0.728


  4 in total

Review 1.  Psychopharmacological Treatment in Older People: Avoiding Drug Interactions and Polypharmacy.

Authors:  Torsten Kratz; Albert Diefenbacher
Journal:  Dtsch Arztebl Int       Date:  2019-07-22       Impact factor: 5.594

2.  Hospitalizations because of adverse drug reactions in elderly patients admitted through the emergency department: a prospective survey.

Authors:  Pascale Olivier; Lionel Bertrand; Marie Tubery; Dominique Lauque; Jean-Louis Montastruc; Maryse Lapeyre-Mestre
Journal:  Drugs Aging       Date:  2009       Impact factor: 3.923

3.  Diuretic drug therapy monitoring in the elderly: a cohort study.

Authors:  Marie Gérardin-Marais; Caroline Victorri-Vigneau; Gwenaëlle Allain-Veyrac; Anicet Chaslerie; Maryse Nicolas; Nathalie Sarraf; Jacques Pivette; Pascale Jolliet
Journal:  Eur J Clin Pharmacol       Date:  2008-01-05       Impact factor: 2.953

Review 4.  Iatrogenic disease in the elderly: risk factors, consequences, and prevention.

Authors:  Sompol Permpongkosol
Journal:  Clin Interv Aging       Date:  2011-03-21       Impact factor: 4.458

  4 in total

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