Literature DB >> 8758042

Tourette's syndrome: a disorder of cingulate and orbitofrontal function?

R A Weeks1, N Turjanski, D J Brooks.   

Abstract

We discuss the clinical characteristics of tics and Tourette's syndrome (TS) and also possible treatment options. Based upon an overview of published pathophysiological and PET data, and the results of a recent PET study of changes in opioid receptor binding in TS, we hypothesize that the disease arises due to dysfunction within the cingulate and orbitofrontal cortex. The beneficial effects of dopamine receptor antagonists and dopamine-depleting agents in TS are suggested to be mediated via basal ganglia-thalamofrontal circuits, while opioid agents may act directly on the cingulate.

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Year:  1996        PMID： 8758042     DOI： 10.1093/qjmed/89.6.401

Source DB:  PubMed          Journal:  QJM        ISSN： 1460-2393


  7 in total

1.  Involvement of insula and cingulate cortices in control and suppression of natural urges.

Authors:  Alicja Lerner; Anto Bagic; Takashi Hanakawa; Eilis A Boudreau; Fernando Pagan; Zoltan Mari; William Bara-Jimenez; Murat Aksu; Susumu Sato; Dennis L Murphy; Mark Hallett
Journal:  Cereb Cortex       Date:  2008-05-09       Impact factor: 5.357

2.  Executive control signals in orbitofrontal cortex during response inhibition.

Authors:  Daniel W Bryden; Matthew R Roesch
Journal:  J Neurosci       Date:  2015-03-04       Impact factor: 6.167

Review 3.  Role of functional imaging in the development and refinement of invasive neuromodulation for psychiatric disorders.

Authors:  Nolan R Williams; Joseph J Taylor; Kayla Lamb; Colleen A Hanlon; E Baron Short; Mark S George
Journal:  World J Radiol       Date:  2014-10-28

Review 4.  Gilles de la Tourette syndrome: symptomatic treatment based on evidence.

Authors:  M M Robertson; J S Stern
Journal:  Eur Child Adolesc Psychiatry       Date:  2000       Impact factor: 4.785

Review 5.  Gilles de la Tourette's syndrome and its impact in the UK.

Authors:  J S Stern; S Burza; M M Robertson
Journal:  Postgrad Med J       Date:  2005-01       Impact factor: 2.401

6.  Widespread abnormality of the γ-aminobutyric acid-ergic system in Tourette syndrome.

Authors:  Alicja Lerner; Anto Bagic; Janine M Simmons; Zoltan Mari; Omer Bonne; Ben Xu; Diane Kazuba; Peter Herscovitch; Richard E Carson; Dennis L Murphy; Wayne C Drevets; Mark Hallett
Journal:  Brain       Date:  2012-05-10       Impact factor: 13.501

7.  Prefrontal and anterior cingulate cortex abnormalities in Tourette Syndrome: evidence from voxel-based morphometry and magnetization transfer imaging.

Authors:  Kirsten R Müller-Vahl; Jörn Kaufmann; Julian Grosskreutz; Reinhard Dengler; Hinderk M Emrich; Thomas Peschel
Journal:  BMC Neurosci       Date:  2009-05-12       Impact factor: 3.288
  7 in total

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